Document Detail


A heparin-like compound isolated from a marine crab rich in glucuronic acid 2-O-sulfate presents low anticoagulant activity.
MedLine Citation:
PMID:  23544586     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A natural heparin-like compound isolated from the crab Goniopsis cruentata was structurally characterized and its anticoagulant and hemorrhagic activities were determined. Enzymatic and nuclear magnetic resonance analysis revealed that its structure is rich in disulfated disaccharides, possessing significant amounts of 2-O-sulfated-β-d-glucuronic acid units. Furthermore, low amounts of trisulfated disaccharide units containing 2-O-sulfated-α-l-iduronic acid were detected, when compared to mammalian heparin. In addition, this heparin-like structure showed negligible in vitro anticoagulant activity and low bleeding potency, facts that make it a suitable candidate for the development of structure-driven, heparin based therapeutic agents with fewer undesirable effects.
Authors:
Giulianna P V Andrade; Marcelo A Lima; Airton A de Souza; Jawed Fareed; Debra A Hoppensteadt; Elizeu A Santos; Suely F Chavante; Fernanda W Oliveira; Hugo A O Rocha; Helena B Nader
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-29
Journal Detail:
Title:  Carbohydrate polymers     Volume:  94     ISSN:  1879-1344     ISO Abbreviation:  Carbohydr Polym     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307156     Medline TA:  Carbohydr Polym     Country:  -    
Other Details:
Languages:  ENG     Pagination:  647-654     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Affiliation:
Departamento de Bioquímica, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
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