| The hemostatic effect of fibrin glue on graft donor sites. | |
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MedLine Citation:
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PMID: 8150838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One of the main uses of topical fibrin glue is hemostasis. Fibrin glue from pooled human plasma has been used in Europe for many years. It was used for fixation of skin grafts as early as 1944. Because of the risk of hepatitis and now of acquired immunodeficiency syndrome, this compound has not been approved by the U.S. Food and Drug Administration for use in the United States. It is now possible to make fibrin glue from a single unit of blood. Many blood banks have this capability, and burn centers in the United States are beginning to report its use in skin grafting procedures performed on patients with burns. In an effort to document a hemostatic effect, a prospective double-blind study was designed. Donor sites of patients with burns undergoing skin grafting were studied to provide a uniform wound; anatomic location varied, particularly with respect to gravity. Half of each donor site was sprayed with thrombin and fibrin glue, and the other half was sprayed with thrombin and placebo. A large absorbent pad was placed over the gauze dressing, and all dressings were collected and weighed by the investigators at 6 and 18 hours after the operation. Ten patients have been studied to date. In five patients slightly more bleeding occurred in the site treated with fibrin. One patient had no difference, and four had slightly less bleeding on the donor site treated with fibrin. No significant difference could be found in this initial study group.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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B M Achauer; S R Miller; T E Lee |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: The Journal of burn care & rehabilitation Volume: 15 ISSN: 0273-8481 ISO Abbreviation: J Burn Care Rehabil Publication Date: 1994 Jan-Feb |
Date Detail:
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Created Date: 1994-05-12 Completed Date: 1994-05-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110188 Medline TA: J Burn Care Rehabil Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 24-8 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of California, Irvine, Orange 92668. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Burns
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surgery* Double-Blind Method Fibrin Tissue Adhesive / therapeutic use* Hemostasis, Surgical* Humans Prospective Studies Skin Transplantation* Thrombin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Tissue Adhesive; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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