Document Detail


The hemolytic and cytolytic activity of group B streptococcal hemolysin and its possible role in early onset group B streptococcal disease.
MedLine Citation:
PMID:  1745564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vitro and cytolytic properties of the hemolysin of group B streptococcus (GBS) were investigated using sheep erythrocytes and McCoy cells adapted for growth in a serum-deficient medium. The relationship between the hemolysin, various carrier molecules and phospholipids was examined. Starch-based carriers interfered with the inhibitory activity of phospholipids and solvents for the phospholipids reduced the activity of the hemolysin. These technical problems were resolved by use of an albumin-based carrier, a strain producing large amounts of hemolysin and sonication of the phospholipid. The hemolysin was cytolytic for McCoy cells and this activity and its hemolytic action on sheep erythrocytes were inhibited by a number of phospholipid components of surfactant. It is possible that GBS hemolysin has a direct or indirect role in the pathogenesis of the pneumonitis of early onset GBS infection.
Authors:
J W Tapsall; E A Phillips
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology     Volume:  23     ISSN:  0031-3025     ISO Abbreviation:  Pathology     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1992-01-15     Completed Date:  1992-01-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0175411     Medline TA:  Pathology     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Prince of Wales Hospital, Syndey.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytotoxins / physiology*
Drug Storage
Hemolysin Proteins / physiology*
Hemolysis / physiology*
Lipids / pharmacology
Phospholipids / pharmacology
Sheep
Streptococcal Infections / physiopathology*
Streptococcus agalactiae / physiology*
Time Factors
Chemical
Reg. No./Substance:
0/Cytotoxins; 0/Hemolysin Proteins; 0/Lipids; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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