Document Detail

The hemoglobin-oxygen equilibrium associated with subunit dissociation.
MedLine Citation:
PMID:  836868     Owner:  NLM     Status:  MEDLINE    
The effect of oxygen-linked tetramer-dimer dissociation on oxygen equilibrium of hemoglobin was investigated by measuring the equilibrium curves over a wide range of protein concentration. A Hill scheme which takes the subunit dissociation into account describes well the overall concentration dependences of the oxygen pressure and slope of the Hill plot at half saturation. Values of dissociation constant for oxyhemoglobin estimated from the equilibrium data agree with the vaues measured by other methods for phosphate-free and diphosphoglycerate-added hemoglobin. The present results indicate that oxygen equilibrium properties are only slightly influenced bysubunit dissociation in the concentration range above 60 muM (as heme) at which most equilibrium experiments have been carried out.
K Imai; H Yonetani
Related Documents :
21885538 - A comparison of external and internal jugular venous pressures to monitor pulmonary art...
21762918 - Coupled fluid-structure interaction hemodynamics in a zero-pressure state corrected art...
21803948 - Improved pulse transit time estimation by system identification analysis of proximal an...
17566188 - Effects of oxygen therapy on left ventricular function in patients with cheyne-stokes r...
23271828 - Chemical oxygen generation.
8104738 - Why do patients with congestive heart failure tolerate the initiation of beta-blocker t...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  490     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-04-15     Completed Date:  1977-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  164-70     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diphosphoglyceric Acids / blood
Oxygen / blood*
Oxyhemoglobins / metabolism*
Phytic Acid / blood
Protein Conformation
Structure-Activity Relationship
Reg. No./Substance:
0/Diphosphoglyceric Acids; 0/Oxyhemoglobins; 7782-44-7/Oxygen; 83-86-3/Phytic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparative immunochemistry of bacterial, algal and plant ferredoxins.
Next Document:  Cleavage of the S-S bond in 5,5'-dithiobis-(2-nitrobenzoic acid) in the presence of a cationic deter...