Document Detail


The hemodynamic effects of intrathecal oxytocin in normal dogs.
MedLine Citation:
PMID:  10871229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the hemodynamic effects produced by intrathecal administration of oxytocin in healthy isoflurane-anesthetized dogs.
STUDY DESIGN: Prospective single-dose trial.
ANIMAL POPULATION: Six healthy purpose-bred adult dogs weighing between 7.3 and 14.5 kg.
METHODS: Dogs were anesthetized with isoflurane and instrumented. Oxytocin at a dosage of 1.6 microg/kg was administered intrathecally at the cisternal space at time 0. Hemodynamic data were recorded immediately before and at 1, 5, 15, 30, and 60 minutes after oxytocin administration. Statistical analysis included an analysis of variance (ANOVA) for repeated measures over time. A P < .05 was considered significant.
RESULTS: Baseline values +/- standard error of the mean for heart rate, mean arterial pressure, central venous pressure, cardiac output, systemic vascular resistance, mean pulmonary arterial pressure, pulmonary arterial occlusion pressure, and pulmonary vascular resistance were 101 +/- 11 beats/minute, 76 +/- 7 mm Hg, 4 +/- 4 mm Hg, 1.9 +/- 0.7 L/min, 3834 +/- 2556 dynes x sec/cm5, 14 +/- 3 mm Hg, 4 +/- 2 mm Hg, and 430 +/- 201 dynes x sec/cm5, respectively. Variations from the baseline values were seen in all parameters after intrathecal oxytocin administration, but no statistically significant differences were found.
CONCLUSION: The intrathecal injection of 1.6 microg/kg of oxytocin is associated with minimal hemodynamic effects during isoflurane anesthesia.
CLINICAL RELEVANCE: This study revealed no clinically significant deleterious effects from the intrathecal administration of oxytocin, and investigations into its use as a perioperative analgesic are therefore warranted.
Authors:
P J Neath; D C Brown; D Hughes; S Z Perkowski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary surgery : VS     Volume:  29     ISSN:  0161-3499     ISO Abbreviation:  Vet Surg     Publication Date:    2000 May-Jun
Date Detail:
Created Date:  2000-07-13     Completed Date:  2000-07-13     Revised Date:  2011-04-25    
Medline Journal Info:
Nlm Unique ID:  8113214     Medline TA:  Vet Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  272-7     Citation Subset:  IM    
Affiliation:
Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Philadelphia 19104-6010, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Dogs / physiology*
Female
Hemodynamics / drug effects*
Injections, Spinal / veterinary
Male
Oxytocin / administration & dosage,  pharmacology*
Prospective Studies
Reference Values
Chemical
Reg. No./Substance:
50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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