| The hemodynamic effects of intrathecal oxytocin in normal dogs. | |
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MedLine Citation:
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PMID: 10871229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the hemodynamic effects produced by intrathecal administration of oxytocin in healthy isoflurane-anesthetized dogs. STUDY DESIGN: Prospective single-dose trial. ANIMAL POPULATION: Six healthy purpose-bred adult dogs weighing between 7.3 and 14.5 kg. METHODS: Dogs were anesthetized with isoflurane and instrumented. Oxytocin at a dosage of 1.6 microg/kg was administered intrathecally at the cisternal space at time 0. Hemodynamic data were recorded immediately before and at 1, 5, 15, 30, and 60 minutes after oxytocin administration. Statistical analysis included an analysis of variance (ANOVA) for repeated measures over time. A P < .05 was considered significant. RESULTS: Baseline values +/- standard error of the mean for heart rate, mean arterial pressure, central venous pressure, cardiac output, systemic vascular resistance, mean pulmonary arterial pressure, pulmonary arterial occlusion pressure, and pulmonary vascular resistance were 101 +/- 11 beats/minute, 76 +/- 7 mm Hg, 4 +/- 4 mm Hg, 1.9 +/- 0.7 L/min, 3834 +/- 2556 dynes x sec/cm5, 14 +/- 3 mm Hg, 4 +/- 2 mm Hg, and 430 +/- 201 dynes x sec/cm5, respectively. Variations from the baseline values were seen in all parameters after intrathecal oxytocin administration, but no statistically significant differences were found. CONCLUSION: The intrathecal injection of 1.6 microg/kg of oxytocin is associated with minimal hemodynamic effects during isoflurane anesthesia. CLINICAL RELEVANCE: This study revealed no clinically significant deleterious effects from the intrathecal administration of oxytocin, and investigations into its use as a perioperative analgesic are therefore warranted. |
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Authors:
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P J Neath; D C Brown; D Hughes; S Z Perkowski |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Veterinary surgery : VS Volume: 29 ISSN: 0161-3499 ISO Abbreviation: Vet Surg Publication Date: 2000 May-Jun |
Date Detail:
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Created Date: 2000-07-13 Completed Date: 2000-07-13 Revised Date: 2011-04-25 |
Medline Journal Info:
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Nlm Unique ID: 8113214 Medline TA: Vet Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 272-7 Citation Subset: IM |
Affiliation:
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Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Philadelphia 19104-6010, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Dogs / physiology* Female Hemodynamics / drug effects* Injections, Spinal / veterinary Male Oxytocin / administration & dosage, pharmacology* Prospective Studies Reference Values |
| Chemical | |
Reg. No./Substance:
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50-56-6/Oxytocin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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