Document Detail

The hemodynamic effects of compliance, bulging, and curvature in a saphenous vein coronary artery bypass graft model.
MedLine Citation:
PMID:  14757922     Owner:  NLM     Status:  MEDLINE    
The development of Intimal Hyperplasia (IH) in saphenous vein coronary artery bypass grafts (SV-CABG) is responsible for the short-term patency of these grafts. Previous studies of SV-CABG models were performed on rigid anastomotic vessels. However, the effects of compliance, bulging and curvature at the anastomosis on the general hemodynamic field, due to compliance and geometric mismatch between the vein and the artery have not been evaluated. We studied axial and transverse velocities by Laser Doppler Velocimetry on a compliant, in vitro, anatomical model of an end-to-side saphenous vein graft (SVG) to left anterior descending (LAD). The model incorporated a bulge at the sinus and curvature at the graft-host junction. Physiologic pressure and flow conditions pertaining to SV-CABG were applied. The presence of the bulge and curvature showed differences in the velocity profiles in comparison with previous rigid model studies. Dynamic separation zones were temporally augmented at the flow divider. The moving stagnation point at the floor of the host vessel was observed to move past the toe of the model during the accelerating portion of the cycle. These findings suggest that the presence of the bulge curvature and compliance may further favor conditions for the development of intimal hyperplasia (IH) at the floor of a CABG.
Pedro D Pedroso; Bradley L Hershey; William Holman; Ramakrishna Venugopalan; Andreas S Anayiotos
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Technology and health care : official journal of the European Society for Engineering and Medicine     Volume:  11     ISSN:  0928-7329     ISO Abbreviation:  Technol Health Care     Publication Date:  2003  
Date Detail:
Created Date:  2004-02-03     Completed Date:  2004-04-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9314590     Medline TA:  Technol Health Care     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  443-55     Citation Subset:  IM    
Department of Biomedical Engineering University of Alabama at Birmingham, Birmingham, AL 35294-4440, USA.
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MeSH Terms
Coronary Artery Bypass*
Laser-Doppler Flowmetry
Models, Biological
Saphenous Vein / physiology,  surgery*
United States

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