Document Detail

The hemodynamic effects of acute myocardial ischemia and reperfusion in Clawn miniature pigs.
MedLine Citation:
PMID:  14562610     Owner:  NLM     Status:  MEDLINE    
Acute myocardial ischemia was induced by occluding the LAD in Clawn miniature pigs. Eight pigs (group 1) were subjected to 6 h ischemia and nine pigs (group 2) were subjected to 20 min ischemia, followed by reperfusion for 340 min. Three animals of the group 1 died due to ventricular fibrillation after occlusion and in group 2, four animals died due to the arrhythmia after reperfusion. Though the ischemic area of group 2 (15.6% of the ventricle) was narrower than that of group 1 (21.7%), the survival rate was lower. We supposed that ischemia-reperfusion injuries were strongly connected with the hemodynamics of group 2. Clawn miniature pigs are useful experimental animals for myocardial ischemic researches.
Ryozo Kamimura; Naoki Miura; Syusaku Suzuki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental animals / Japanese Association for Laboratory Animal Science     Volume:  52     ISSN:  1341-1357     ISO Abbreviation:  Exp. Anim.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-10-17     Completed Date:  2003-11-07     Revised Date:  2014-10-24    
Medline Journal Info:
Nlm Unique ID:  9604830     Medline TA:  Exp Anim     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  335-8     Citation Subset:  IM    
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MeSH Terms
Hemodynamics / physiology*
Myocardial Reperfusion Injury / physiopathology*
Swine, Miniature / physiology*

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