Document Detail


The hemodynamic effect of the support mode for the intra-aorta pump on the cardiovascular system.
MedLine Citation:
PMID:  23379287     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Intra-aorta pump is a novel rotary ventricular assist device. Because of the special structure and connection with the native heart, the hemodynamic effect of support mode of this pump on the cardiovascular system is not clear. In this work, three support modes, including "constant speed" mode, "co-pulse" mode, and "counter-pulse" mode, have been designed for the intra-aorta pump to evaluate the hemodynamic effect of different support modes on the cardiovascular system. Simulation results demonstrate that that both "co-pulse" mode and "counter-pulse" mode can achieve better unloading performance than "constant speed" mode. The intra-aorta pump controlled by "co-pulse" mode is beneficial for improving coronary flow. Moreover, the external work, which is defined as the product of left ventricular pressure and cardiac output, under "co-pulse" mode is the minimum of the three support modes (0.783 w vs. 0.615 w vs. 0.702 w). The pulsatility ratio, defined as the ratio of the peak-to-peak value of arterial pressure (AP) to the mean arterial pressure value, under "co-pulse" mode is the maximum of the three modes (24% vs. 32.8% vs. 23.7%). The equivalent afterload value, which is the ratio of pulsatile pressure at the pump inflow and pulsatile pump flow, is larger than other support modes (0.596 mm Hg.s/mL vs. 0.9704 mm Hg.s/mL vs. 0.55 mm Hg.s/mL). In brief, the intra-aorta pump under "co-pulse" mode support is beneficial for improving myocardial perfusion and restoring pulsatility of AP, while "counter-pulse" mode is beneficial to the perfusion of vital organs.
Authors:
Bin Gao; Yu Chang; Yanjiao Xuan; Yi Zeng; Youjun Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Artificial organs     Volume:  37     ISSN:  1525-1594     ISO Abbreviation:  Artif Organs     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-65     Citation Subset:  IM    
Copyright Information:
© 2013, Copyright the Authors. Artificial Organs © 2013, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
Affiliation:
School of Life Science and BioEngineering, Beijing University of Technology, Beijing, China.
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