Document Detail

Is hemifacial microsomia linked to multiple maternities?
MedLine Citation:
PMID:  12479420     Owner:  NLM     Status:  MEDLINE    
Hemifacial microsomia describes a congenital orofacial malformation in which there is insufficient or disrupted development of the mandible affecting one side of the face. The aetiology of this condition remains unclear, but it has been postulated that twins (predominantly monozygotic) are more liable to be affected than singletons. This study investigates the incidence of multiple births amongst a large number of affected individuals and their families. Data were collected on 145 individuals with hemifacial microsomia and microtia, using postal questionnaires and interviews in a hospital setting. These data were compared with the mean age-standardised twin maternity prevalence for England and Wales between 1975 and 1995 of 1.06% and the triplet maternity prevalence for England and Wales for 1995 of 0.034% (a multiple maternity being where more than one baby is born, either alive or stillborn). The prevalence of twin maternities amongst the affected individuals was 3.96% (P>0.05) and amongst their siblings it was 4.02% (P<0.02). There was also an excess of twins in the rest of the family groups, predominantly due to a stronger history of twinning on the maternal side. As there were more twins amongst the affected individuals than in the general population, it seems likely that whatever the aetiology of hemifacial microsomia and microtia, the presence of a co-twin (or co-triplets) may make the causal event, or series of causal events, more likely to occur. This study supports the hypothesis that hemifacial microsomia and microtia are in some way linked to multiple births. Analysis of this link may provide new directions for research into the aetiology of a variety of congenital defects.
K Lawson; N Waterhouse; D T Gault; M L Calvert; M Botma; R Ng
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of plastic surgery     Volume:  55     ISSN:  0007-1226     ISO Abbreviation:  Br J Plast Surg     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-12-13     Completed Date:  2003-01-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2984714R     Medline TA:  Br J Plast Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  474-8     Citation Subset:  IM    
Craniofacial Unit, Chelsea and Westminster Hospital, London, UK.
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MeSH Terms
Diseases in Twins
Facial Asymmetry / etiology*
Microstomia / etiology*
Twins, Dizygotic
Twins, Monozygotic

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