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hebp3, a Novel Member of the Heme-Binding Protein Gene Family, Is Expressed in the Medaka Meninges With Higher Abundance in Females Due to a Direct Stimulating Action of Ovarian Estrogens.
MedLine Citation:
PMID:  23284102     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The brains of teleost fish exhibit remarkable sexual plasticity throughout their life span. To dissect the molecular basis for the development and reversal of sex differences in the teleost brain, we screened for genes differentially expressed between sexes in the brain of medaka (Oryzias latipes). One of the genes identified in the screen as being preferentially expressed in females was found to be a new member of the heme-binding protein gene family that includes hebp1 and hebp2 and was designated here as hebp3. The medaka hebp3 is expressed in the meninges with higher abundance in females, whereas there is no expression within the brain parenchyma. This female-biased expression of hebp3 is not attributable to the direct action of sex chromosome genes but results from the transient and reversible action of estrogens derived from the ovary. Moreover, estrogens directly activate the transcription of hebp3 via a palindromic estrogen-responsive element in the hebp3 promoter. Taken together, our findings demonstrate that hebp3 is a novel transcriptional target of estrogens, with female-biased expression in the meninges. The definite but reversible sexual dimorphism of the meningeal hebp3 expression may contribute to the development and reversal of sex differences in the teleost brain.
Authors:
Kiyoshi Nakasone; Yoshitaka Nagahama; Kataaki Okubo
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-2
Journal Detail:
Title:  Endocrinology     Volume:  -     ISSN:  1945-7170     ISO Abbreviation:  Endocrinology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Aquatic Bioscience (K.N., K.O.), Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan; Laboratory of Reproductive Biology (Y.N.), National Institute for Basic Biology, Okazaki, Aichi 444-8585, Japan; and Institution for Collaborative Relations (Y.N.), Ehime University, Matsuyama, Ehime 791-0295, Japan.
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