Document Detail


Is heart rate variability related to gait impairment in patients with Parkinson's disease? A pilot study.
MedLine Citation:
PMID:  19329349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Impairments in gait and autonomic function are common in patients with Parkinson's disease (PD). These are likely independent symptoms, based on different etiologic mechanisms. However, a few recent reports have observed an association between motor function, in particular gait impairment, and autonomic function in PD. In those studies, the Unified Parkinson's Disease Rating Scale (UPDRS) was used to evaluate gait and motor function. The present study was performed to further examine this putative relationship using quantitative measures of autonomic function and gait in order to shed light on the underlying pathophysiology of these symptoms.
METHODS: Nine healthy young, 15 healthy elderly and 18 PD patients were studied. Heart rate variability (HRV) measures were collected during rest. Gait speed, swing time and swing time variability were measured during a 1-min walk at comfortable speed. The motor portion of the UPDRS was also evaluated in all subjects.
RESULTS: HRV values were highest in the young adults, intermediate in the healthy elderly controls, and lowest in the PD patients. Gait measures tended to deteriorate with age and were significantly worse in the PD patients, compared to the elderly controls. HRV was not correlated with any measure of gait performance (p>0.129) nor with the UPDRS-motor score (p>0.147).
DISCUSSION AND CONCLUSIONS: The present findings support the idea that gait and autonomic function impairments co-exist in PD, but their etiology is based on distinct pathophysiological pathways, with minimal overlap.
Authors:
M B Aerts; N E Synhaeve; A Mirelman; B R Bloem; N Giladi; J M Hausdorff
Related Documents :
8848209 - S-methylation in parkinson's disease.
14569099 - Obesity is associated with worse peritoneal dialysis outcomes in the australia and new ...
9521259 - Long-term progression in chronic manganism: ten years of follow-up.
8210229 - The relationship of essential tremor to other movement disorders: report on 678 patient...
2348189 - Syntax comprehension deficits in parkinson's disease.
11240569 - Reversible parkinsonism and hyperammonemia associated with portal vein thrombosis.
9572639 - Double-negative (cd4-cd8-) tcralphabeta+ cells in patients with systemic lupus erythema...
23600689 - Assessment and management of iron overload in β-thalassaemia major patients during the...
18069419 - Bone turnover and hip bone mineral density in patients with sarcoidosis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-28
Journal Detail:
Title:  Parkinsonism & related disorders     Volume:  15     ISSN:  1873-5126     ISO Abbreviation:  Parkinsonism Relat. Disord.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-27     Completed Date:  2010-01-08     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  9513583     Medline TA:  Parkinsonism Relat Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  712-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Autonomic Nervous System / physiopathology*
Female
Gait / physiology*
Heart Rate / physiology*
Humans
Male
Parkinson Disease / physiopathology*
Pilot Projects
Psychomotor Performance / physiology
Grant Support
ID/Acronym/Agency:
P60 AG008812-129005/AG/NIA NIH HHS; R01 HD039838-01/HD/NICHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Study on changes of MMP-3 expression after brain contusion in rats.
Next Document:  Health-related quality of life and alternative forms of exercise in Parkinson disease.