| The heart rate response to exercise and circulating catecholamines in heart transplant recipients. | |
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MedLine Citation:
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PMID: 11810205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The plasma concentration of noradrenaline ([NA]) is higher than that of adrenaline ([A]) both in normal subjects and in heart transplant recipients (HTR). Since in both groups the myocardial density of beta1-adrenergenic receptors is much greater than that of beta2-adrenergenic receptors, the chronotropic response of a denervated heart to changes in plasma [NA] and [A] in the absence of reinnervation should be similar to that of agonist stimulation of beta1-receptors. To test this hypothesis, 17 HTR and 9 healthy subjects (CTL) performed incremental exercise on a cycle ergometer to voluntary exhaustion. Heart rate (HR) was recorded by electrocardiography. [NA] and [A] were measured by high-pressure liquid chromatography at rest and at increasing workloads (w). In both groups, HR and [NA+A] increased with w, and HR with [NA+A]. Normalized HR values, plotted against the logarithm of [NA+A], fitted significantly logistic curves. The affinity constants were different, i.e. 2599+/-350 and 487+/-37 ng.l(-1), for HTR and CTL, respectively. The chronotropic effect of changes in [NA+A] in HTR was similar to that of combined beta1- and beta2-adrenergic activation evoked by applying isoprenaline to isolated heart myocytes (Brodde OE, Pharmacol Ther 60:405-430, 1993). These findings suggest that over time sympathetic reinnervation and the modulation of beta-receptors may take place in HTR, ruling out the hypothesis of persistent heart denervation. |
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Authors:
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Guido Ferretti; Claudio Marconi; Guido Achilli; Elisabetta Caspani; Roberto Fiocchi; Filippo Mamprin; Amando Gamba; Paolo Ferrazzi; Paolo Cerretelli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2001-09-28 |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 443 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-01-25 Completed Date: 2002-04-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: Germany |
Other Details:
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Languages: eng Pagination: 370-6 Citation Subset: IM |
Affiliation:
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Département de Physiologie, Centre Médical Universitaire, 1 rue Michel Servet, 1211 Genève 4, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Epinephrine / blood* Exercise / physiology* Exercise Test Female Heart / innervation, physiology Heart Rate / physiology* Heart Transplantation / physiology* Humans Male Norepinephrine / blood* Receptors, Adrenergic, beta-1 / physiology Receptors, Adrenergic, beta-2 / physiology Sympathetic Nervous System / physiology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic, beta-1; 0/Receptors, Adrenergic, beta-2; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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