| The heart in hypertension and arrhythmias. | |
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MedLine Citation:
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PMID: 2138116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antihypertensive management reduces the incidence of congestive heart failure, malignant hypertension and stroke; however, the overall incidence of events due to ischemic heart disease was not influenced by antihypertensive treatment. One of the possible explanations might be some negative metabolic effects of antihypertensive drugs. Hypokalemia develops in 20 to 50% patients who receive a thiazide diuretic. An association between hypokalemia and malignant arrhythmias (including ventricular fibrillation), in acute myocardial infarction, has been observed. 24-hour ambulatory electrocardiographic monitoring demonstrated a higher frequency of ventricular ectopic beats in hypertensive patients taking thiazides. There is, however, no convincing evidence of a simple causative relation between ventricular extrasystoles and low concentrations of serum potassium. Hypertensives with left ventricular hypertrophy (ECG criteria) had significantly more premature ventricular contractions than patients with established hypertension without left ventricular hypertrophy or normotensive subjects. These data could provide an electrophysiologic substrate for the epidemiologic findings of increased morbidity and mortality in patients with left ventricular hypertrophy. |
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Authors:
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J Widimský; R Cífková |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Herz Volume: 15 ISSN: 0340-9937 ISO Abbreviation: Herz Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1990-04-25 Completed Date: 1990-04-25 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7801231 Medline TA: Herz Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 49-53 Citation Subset: IM |
Affiliation:
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Institute for Postgraduate Medical Education, Department of Cardiology, Prague, Czechoslovakia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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adverse effects Cardiomegaly / complications* Death, Sudden / etiology* Electrocardiography, Ambulatory Humans Hypertension / complications* Risk Factors Tachycardia / complications* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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