Document Detail


The heart disease of Friedreich's ataxia: a clinical and electrocardiographic study of 115 patients, with an analysis of serial electrocardiographic changes in 30 cases.
MedLine Citation:
PMID:  6228949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One hundred and fifteen patients with carefully defined Friedreich's ataxia were assessed clinically and electrocardiographically for evidence of heart disease. Cardiac symptoms, of which dyspnoea and palpitations were the most frequent, occurred in less than 30 per cent. Abnormalities on clinical examination were present in a similar proportion; harsh systolic murmurs, ventricular hypertrophy and added heart sounds were the commonest of these. Cardiac failure and persistent arrhythmias were rare and occurred late in the evolution of the neurological disease. Two patients presented with heart disease before developing neurological symptoms. Cardiac signs and symptoms were uncommon in patients without electrocardiographic abnormalities. About two-thirds of the cases had definitely abnormal ECG recordings. The characteristic finding was of widespread T-wave inversion with ventricular hypertrophy. Serial ECGs, recorded over periods of up to 32 years, were available in 30 cases and showed that abnormalities may develop in patients with Friedreich's ataxia at any time up until 20 years after the onset of neurological symptoms. In four patients initial ECG abnormalities had either improved or disappeared subsequently.
Authors:
A E Harding; R L Hewer
Related Documents :
24905889 - Intravenous xenogeneic transplantation of human adipose-derived stem cells improves lef...
23482079 - Alcohol consumption and 5-year change in left atrial volume among patients with coronar...
910679 - Diagnosis of right ventricular infarction: experimental study through the use of body s...
24967059 - Values of troponin t and myoglobin predictive of non-cardiac ischemia in rats.
21384079 - Paradoxical excess mortality in the plato trial should be independently verified.
24717469 - Minimizing door-to-balloon time is not the most critical factor in improving clinical o...
7564449 - Adequate distribution of warm cardioplegic solution.
23613699 - Coronary slow flow phenomenon leads to st elevation myocardial infarction.
18476979 - Role of transesophageal echocardiography in percutaneous aortic valve replacement with ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Quarterly journal of medicine     Volume:  52     ISSN:  0033-5622     ISO Abbreviation:  Q. J. Med.     Publication Date:  1983  
Date Detail:
Created Date:  1984-02-24     Completed Date:  1984-02-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401027     Medline TA:  Q J Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  489-502     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Arrhythmias, Cardiac / etiology
Cardiomegaly / etiology
Child
Dyspnea / etiology
Electrocardiography
Female
Follow-Up Studies
Friedreich Ataxia / complications*,  physiopathology
Heart / physiopathology
Heart Diseases / etiology*
Humans
Male
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effect of low doses of d-amphetamine on drug-induced hyperactivity in the mouse.
Next Document:  Acute exposure to pulsed microwaves affects neither pentylenetetrazol seizures in the rat nor chlord...