| The heart and development. | |
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MedLine Citation:
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PMID: 9090776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The perspective from which the developing heart is viewed can lead to differing conclusions about the effects of development on cardiac function. The hearts of the embryo, fetus and adult, viewed from a global perspective, sustain the circulation through the same basic mechanisms of developing pressure and ejecting blood. The failure of the embryonic heart to perform these tasks results in growth failure, edema, and embryonic death, just as in the infant and adult such failure results in premature death. Furthermore, from the viewpoint of gross anatomy, following embryonic morphogenesis, the developing and adult hearts appear in general to be structurally similar, differing only in size and mass. However, a closer view shows, in the molecular and structural makeup of the myocardium, richly complex changes that can modulate the basic physiological properties of the cardiac myocyte. This article focuses on how these changes and the effects of birth and development alter ventricular function. |
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Authors:
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P A Anderson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in perinatology Volume: 20 ISSN: 0146-0005 ISO Abbreviation: Semin. Perinatol. Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-05-29 Completed Date: 1997-05-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 482-509 Citation Subset: IM |
Affiliation:
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Department of Pediatric Cardiology, Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acid Sequence Animals Base Sequence Contractile Proteins / chemistry, genetics, physiology Heart / embryology*, growth & development*, physiology Humans Molecular Sequence Data Morphogenesis Myocardium / ultrastructure Myofibrils / ultrastructure |
| Chemical | |
Reg. No./Substance:
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0/Contractile Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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