Document Detail

The heart as a self-regulating system: integration of homeodynamic mechanisms.
MedLine Citation:
PMID:  9134627     Owner:  NLM     Status:  MEDLINE    
In the past the study of mechanical and electrical properties of the heart has been disjointed with minimal overlap and unification. The fact remains that these features are tightly coupled and central to the functioning heart. The maintenance of adequate cardiac output relies upon the highly integrated autoregulatory mechanisms and modulation of cardiac myocyte function. Regional ventricular mechanics and energetics are dependent upon muscle fiber stress-strain rate, the passive properties of myocardial collagen matrix, adequate vascular perfusion, transcapillary transport and electrical activation pattern. Intramural hydraulic "loading" is regulated by coronary arterial and venous dynamics. All of these components are under the constant influence of intrinsic cardiac and extracardiac autonomic neurons, as well as circulating hormones. A brief overview of the putative regulation of these various components is presented in this paper.
J Y Kresh; J A Armour
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Technology and health care : official journal of the European Society for Engineering and Medicine     Volume:  5     ISSN:  0928-7329     ISO Abbreviation:  Technol Health Care     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-10     Completed Date:  1997-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9314590     Medline TA:  Technol Health Care     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  159-69     Citation Subset:  IM; S    
Department of Cardiothoracic Surgery and Medicine, Medical College of Pennsylvania, Philadelphia, USA.
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MeSH Terms
Autonomic Pathways / physiology
Cardiac Output*
Heart / physiology*
Models, Cardiovascular*
Myocardium / ultrastructure
Myofibrils / physiology,  ultrastructure
Neurotransmitter Agents / physiology
Ventricular Function
Reg. No./Substance:
0/Neurotransmitter Agents

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