| The heart as a self-regulating system: integration of homeodynamic mechanisms. | |
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MedLine Citation:
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PMID: 9134627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the past the study of mechanical and electrical properties of the heart has been disjointed with minimal overlap and unification. The fact remains that these features are tightly coupled and central to the functioning heart. The maintenance of adequate cardiac output relies upon the highly integrated autoregulatory mechanisms and modulation of cardiac myocyte function. Regional ventricular mechanics and energetics are dependent upon muscle fiber stress-strain rate, the passive properties of myocardial collagen matrix, adequate vascular perfusion, transcapillary transport and electrical activation pattern. Intramural hydraulic "loading" is regulated by coronary arterial and venous dynamics. All of these components are under the constant influence of intrinsic cardiac and extracardiac autonomic neurons, as well as circulating hormones. A brief overview of the putative regulation of these various components is presented in this paper. |
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Authors:
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J Y Kresh; J A Armour |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Technology and health care : official journal of the European Society for Engineering and Medicine Volume: 5 ISSN: 0928-7329 ISO Abbreviation: Technol Health Care Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-07-10 Completed Date: 1997-07-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9314590 Medline TA: Technol Health Care Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 159-69 Citation Subset: IM; S |
Affiliation:
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Department of Cardiothoracic Surgery and Medicine, Medical College of Pennsylvania, Philadelphia, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autonomic Pathways
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physiology Biomechanics Cardiac Output* Heart / physiology* Homeostasis* Humans Models, Cardiovascular* Myocardium / ultrastructure Myofibrils / physiology, ultrastructure Neurotransmitter Agents / physiology Ventricular Function |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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