Document Detail

The health benefits of calcium citrate malate: a review of the supporting science.
MedLine Citation:
PMID:  18291308     Owner:  NLM     Status:  MEDLINE    
There has been considerable investigation into the health benefits of calcium citrate malate (CCM) since it was first patented in the late 1980s. This chapter is a comprehensive summary of the supporting science and available evidence on the bioavailability and health benefits of consuming CCM. It highlights the important roles that CCM can play during various life stages. CCM has been shown to facilitate calcium retention and bone accrual in children and adolescents. In adults, it effectively promotes the consolidation and maintenance of bone mass. In conjunction with vitamin D, CCM also decreases bone fracture risk in the elderly, slows the rate of bone loss in old age, and is of benefit to the health and well-being of postmenopausal women. CCM is exceptional in that it confers many unique benefits that go beyond bone health. Unlike other calcium sources that necessitate supplementation be in conjunction with a meal to ensure an appreciable benefit is derived, CCM can be consumed with or without food and delivers a significant nutritional benefit to individuals of all ages. The chemistry of CCM makes it a particularly beneficial calcium source for individuals with hypochlorydia or achlorydia, which generally includes the elderly and those on medications that decrease gastric acid secretion. CCM is also recognized as a calcium source that does not increase the risk of kidney stones, and in fact it protects against stone-forming potential. The versatile nature of CCM makes it a convenient and practical calcium salt for use in moist foods and beverages. The major factor that may preclude selection of CCM as a preferred calcium source is the higher cost compared to other sources of calcium commonly used for fortification (e.g., calcium carbonate and tricalcium phosphate). However, formation of CCM directly within beverages or other fluid foods and/or preparations, and the addition of a concentrated CCM solution or slurry, are relatively cost-effective methods by which CCM can be incorporated into finished food and beverage products.
Susan Reinwald; Connie M Weaver; Jeffrey J Kester
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in food and nutrition research     Volume:  54     ISSN:  1043-4526     ISO Abbreviation:  Adv. Food Nutr. Res.     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-22     Completed Date:  2008-05-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001271     Medline TA:  Adv Food Nutr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-346     Citation Subset:  IM    
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA.
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MeSH Terms
Biological Availability
Blood Pressure / drug effects,  physiology
Bone Density / drug effects*,  physiology
Bone Density Conservation Agents / metabolism,  pharmacokinetics*
Calcium / physiology*
Calcium, Dietary / metabolism,  pharmacokinetics*
Citric Acid
Dietary Supplements
Food, Fortified
Intestinal Absorption
Nutritional Requirements*
Oral Health
Osteoporosis / prevention & control
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Calcium, Dietary; 0/Malates; 142606-53-9/calcium citrate malate; 7440-70-2/Calcium; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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