| The hard life of soft cells. | |
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MedLine Citation:
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PMID: 19479819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cells are mechanical as well as chemical machines, and much of the energy they consume is used to apply forces to each other and to the extracellular matrix around them. The cytoskeleton, the cell membrane, and the macromolecules composing the extracellular matrix form networks that in concert with the forces generated by the cell create dynamic materials with viscoelastic properties unique to each tissue. Numerous recent studies suggest that the forces that cells create and are subjected to, as well as the mechanical properties of the materials to which they adhere, can have large effects on cell structure and function that can act in concert with or override signals from soluble stimuli. This brief review summarizes recent studies of the effects of substrate mechanics on cell motility, differentiation, and proliferation, and discusses possible mechanisms by which a cell can probe the stiffness of its surroundings. Cell Motil. Cytoskeleton, 2009. (c) 2009 Wiley-Liss, Inc. |
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Authors:
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Paul A Janmey; Jessamine P Winer; Maria E Murray; Qi Wen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cell motility and the cytoskeleton Volume: 66 ISSN: 1097-0169 ISO Abbreviation: Cell Motil. Cytoskeleton Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-16 Completed Date: 2009-10-13 Revised Date: 2012-07-02 |
Medline Journal Info:
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Nlm Unique ID: 8605339 Medline TA: Cell Motil Cytoskeleton Country: United States |
Other Details:
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Languages: eng Pagination: 597-605 Citation Subset: IM |
Affiliation:
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Department of Physiology, Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Laboratories, Philadelphia, Pennsylvania, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomechanics / physiology* Cell Differentiation / physiology Cell Movement / physiology Cell Proliferation Cells / cytology*, metabolism* Humans Mechanotransduction, Cellular / physiology Models, Biological |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM083272/GM/NIGMS NIH HHS; R01 GM083272-02/GM/NIGMS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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