Document Detail

The hard life of soft cells.
MedLine Citation:
PMID:  19479819     Owner:  NLM     Status:  MEDLINE    
Cells are mechanical as well as chemical machines, and much of the energy they consume is used to apply forces to each other and to the extracellular matrix around them. The cytoskeleton, the cell membrane, and the macromolecules composing the extracellular matrix form networks that in concert with the forces generated by the cell create dynamic materials with viscoelastic properties unique to each tissue. Numerous recent studies suggest that the forces that cells create and are subjected to, as well as the mechanical properties of the materials to which they adhere, can have large effects on cell structure and function that can act in concert with or override signals from soluble stimuli. This brief review summarizes recent studies of the effects of substrate mechanics on cell motility, differentiation, and proliferation, and discusses possible mechanisms by which a cell can probe the stiffness of its surroundings. Cell Motil. Cytoskeleton, 2009. (c) 2009 Wiley-Liss, Inc.
Paul A Janmey; Jessamine P Winer; Maria E Murray; Qi Wen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cell motility and the cytoskeleton     Volume:  66     ISSN:  1097-0169     ISO Abbreviation:  Cell Motil. Cytoskeleton     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-16     Completed Date:  2009-10-13     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  8605339     Medline TA:  Cell Motil Cytoskeleton     Country:  United States    
Other Details:
Languages:  eng     Pagination:  597-605     Citation Subset:  IM    
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MeSH Terms
Biomechanical Phenomena / physiology*
Cell Differentiation / physiology
Cell Movement / physiology
Cell Proliferation
Cells / cytology*,  metabolism*
Mechanotransduction, Cellular / physiology
Models, Biological
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