Document Detail

A halothane-induced biochemical defect in muscle of normal and malignant hyperthermia-susceptible Landrace pigs.
MedLine Citation:
PMID:  7189363     Owner:  NLM     Status:  MEDLINE    
Muscle adenosine triphosphate (ATP), glucose-6-phosphate, phosphocreatine, and pH were measured in nine malignant hyperthermia (MH)-susceptible and 14 MH-resistant Landrace pigs. Muscle biopsies were taken before (under barbiturate anesthesia) and after exposure to halothane. When compared to levels during barbiturate anesthesia, exposure to halothane had no immediate effect on muscle ATP levels in either MH-susceptible or -resistant pigs. However, once malignant hyperthermia developed in susceptibe pigs ATP levels decreased significantly. In both susceptible and resistant pigs halothane increased muscle glucose-6-phosphate and decreased muscle phosphocreatine and pH significantly below control levels observed during barbiturate anesthesia. In susceptible pigs these changes were significantly more marked than were the changes produced in resistant pigs. These data indicate that the effect of halothane on muscle metabolism is similar in both MH-resistant and -susceptible pigs. The results suggest that the effect of halothane is to inhibit aerobic metabolism by preventing mitochondrial dehydrogenation of pyruvate. Inhibition is complete in susceptible pigs but only retarded in resistant pigs. In susceptible pigs the consequent lactacidosis, hyperthermia, and reduction in ATP synthesis contribute to the development and maintenance of rigidity.
G Mitchell; J J Heffron; A J van Rensburg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  59     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-06-27     Completed Date:  1980-06-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  250-6     Citation Subset:  AIM; IM    
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MeSH Terms
Adenosine Triphosphate / analysis
Body Temperature
Glucosephosphates / analysis
Halothane / pharmacology*
Hydrogen-Ion Concentration
Malignant Hyperthermia / chemically induced,  metabolism*
Muscles / metabolism*
Phosphocreatine / analysis
Swine / physiology*
Reg. No./Substance:
0/Glucosephosphates; 151-67-7/Halothane; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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