| The hairy ears (Eh) mutation is closely associated with a chromosomal rearrangement in mouse chromosome 15. | |
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MedLine Citation:
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PMID: 2272507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mouse mutation hairy ears (Eh) originated in a neutron irradiation experiment at Oak Ridge National Laboratory. Subsequent linkage studies with Eh and other loci on Chr 15 suggested that it is associated with a chromosomal rearrangement that inhibits recombination since it shows tight linkage with several loci occupying the region extending from congenital goiter (cog) distal to caracul (Ca). We report here (1) linkage experiments confirming this effect on recombination and (2) meiotic and mitotic cytological studies that confirm the presence of a chromosomal rearrangement. The data are consistent with the hypothesis of a paracentric inversion in the distal half of Chr 15. The effect of the inversion extends over a minimum of 30 cM, taking into account the genetic data and the cytologically determined chromosomal involvement extending to the region of the telomere. |
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Authors:
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M T Davisson; T H Roderick; E C Akeson; N L Hawes; H O Sweet |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Genetical research Volume: 56 ISSN: 0016-6723 ISO Abbreviation: Genet. Res. Publication Date: 1990 Oct-Dec |
Date Detail:
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Created Date: 1991-02-22 Completed Date: 1991-02-22 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0370741 Medline TA: Genet Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 167-78 Citation Subset: IM |
Affiliation:
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Jackson Laboratory, Bar Harbor, ME 04609. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromosome Inversion* Crosses, Genetic Female Linkage (Genetics)* Male Meiosis Mice Mice, Inbred C57BL Mitosis Mutation* Phenotype Recombination, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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GM19656/GM/NIGMS NIH HHS; RR01183/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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