Document Detail


The haemodynamics of septic shock.
MedLine Citation:
PMID:  2289987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Both peripheral vascular abnormalities and changes in myocardial function are hallmarks of septic shock. Their complex interactions result in inadequate and maldistributed microcirculatory flow and progressive organ dysfunction. Inappropriate vasodilation, microembolization and endothelial cell injury are proposed mechanisms that may induce maldistribution of flow in the microcirculation and inefficient, defective peripheral oxygen extraction. Abnormal myocardial function is manifested by diminished right and left ventricular ejection fractions, ventricular dilatation, altered Frank-Starling curves and diastolic pressure-volume relationships. These changes are already observed in an early stage of septic shock and are entirely reversible in survivors.
Authors:
L G Thijs; A J Schneider; A B Groeneveld
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Intensive care medicine     Volume:  16 Suppl 3     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1990  
Date Detail:
Created Date:  1991-04-03     Completed Date:  1991-04-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S182-6     Citation Subset:  IM    
Affiliation:
Medical Intensive Care Unit, Free University Hospital, Amsterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Blood Circulation
Hemodynamics*
Humans
Myocardial Contraction
Oxygen Consumption
Shock, Septic / metabolism,  pathology,  physiopathology*
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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