Document Detail

The haemodynamics of septic shock.
MedLine Citation:
PMID:  2289987     Owner:  NLM     Status:  MEDLINE    
Both peripheral vascular abnormalities and changes in myocardial function are hallmarks of septic shock. Their complex interactions result in inadequate and maldistributed microcirculatory flow and progressive organ dysfunction. Inappropriate vasodilation, microembolization and endothelial cell injury are proposed mechanisms that may induce maldistribution of flow in the microcirculation and inefficient, defective peripheral oxygen extraction. Abnormal myocardial function is manifested by diminished right and left ventricular ejection fractions, ventricular dilatation, altered Frank-Starling curves and diastolic pressure-volume relationships. These changes are already observed in an early stage of septic shock and are entirely reversible in survivors.
L G Thijs; A J Schneider; A B Groeneveld
Related Documents :
3332227 - Catecholamines in critical care.
7658617 - A case of unprotected left main coronary stenosis rescued by directional coronary ather...
19946587 - Tenecteplase for st-elevation myocardial infarction in a patient treated with drotrecog...
19963687 - Optimizing cardiac resuscitation outcomes using wavelet analysis.
3039187 - Prognostic value and limitation of doughnut pattern of technetium-99m pyrophosphate myo...
16697317 - Sites of focal atrial activity characterized by endocardial mapping during atrial fibri...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Intensive care medicine     Volume:  16 Suppl 3     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1990  
Date Detail:
Created Date:  1991-04-03     Completed Date:  1991-04-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S182-6     Citation Subset:  IM    
Medical Intensive Care Unit, Free University Hospital, Amsterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Circulation
Myocardial Contraction
Oxygen Consumption
Shock, Septic / metabolism,  pathology,  physiopathology*
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Practical points in the application of oxygen transport principles.
Next Document:  A model for the interplay of inflammatory mediators in sepsis--a study in 48 patients.