Document Detail

The haemodynamic effects of propofol and thiopentone for induction of caesarean section.
MedLine Citation:
PMID:  2368889     Owner:  NLM     Status:  MEDLINE    
Forty Chinese women for elective caesarean section received either propofol 2 or thiopentone 4 for induction of general anaesthesia. Systolic, mean and diastolic arterial pressures and heart rate were recorded non-invasively every minute for ten minutes. Post-induction arterial pressures were similar to pre-induction values with no differences between thiopentone and propofol. Following intubation, the rise in systolic arterial pressure was greater in the thiopentone group, 32.1 mmHg (SD 23.7) compared with the propofol group, 17.4 mmHg (SD 23.8), (P less than 0.05). In the thiopentone group, arterial pressures were slower in returning to baseline values. Heart rate was initially elevated in both groups to the same degree. At caesarean section, induction with propofol causes less variation in arterial pressure than thiopentone. Hypotension is probably prevented by the coincident stimulus of rapid sequence induction. Neonatal Apgar scores were similar between the two groups.
T Gin; M A Gregory; T E Oh
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  18     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-13     Completed Date:  1990-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  175-9     Citation Subset:  IM    
Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N.T.
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MeSH Terms
Anesthesia, Intravenous*
Anesthesia, Obstetrical*
Apgar Score
Blood Pressure / drug effects*
Cesarean Section*
Electrocardiography / drug effects
Heart Rate / drug effects*
Infant, Newborn
Intubation, Intratracheal
Propofol / pharmacology*
Random Allocation
Thiopental / pharmacology*
Time Factors
Reg. No./Substance:
2078-54-8/Propofol; 76-75-5/Thiopental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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