Document Detail

hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein.
MedLine Citation:
PMID:  11867227     Owner:  NLM     Status:  MEDLINE    
We have identified a novel human gene UNC93B1 encoding a protein related to unc-93 of Caenorhabditis elegans. The combined sequence derived from several cDNA clones is 2282 bp and comparison with genomic sequence shows that the gene contains 11 exons. The longest open reading frame encodes a deduced sequence of 597 amino acids. Homology analysis shows that the hUNC93B1 gene is highly conserved and related to sequences in Arabidopsis thaliana, C. elegans, Drosophila melanogaster, chicken and mouse. Structural analysis of the deduced amino acid sequence of hUNC93B1 points to possible existence of multiple membrane-spanning domains. hUNC93B1 protein also displays some similarities to the bacterial ABC-2 type transporter signature and to ion transporters of Deinococcus radiodurans and Helicobacter pylori. As revealed by Northern analysis, the level of expression varies significantly between tissues, with the highest level detected in the heart. The gene was mapped to chromosomal band 11q13 by fluorescence in situ hybridization. We suggest that this gene is a member of a novel hUNC93B-related gene family.
Vladimir I Kashuba; Alexei I Protopopov; Sergei M Kvasha; Rinat Z Gizatullin; Claes Wahlestedt; Lev L Kisselev; George Klein; Eugene R Zabarovsky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gene     Volume:  283     ISSN:  0378-1119     ISO Abbreviation:  Gene     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-27     Completed Date:  2002-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  209-17     Citation Subset:  IM    
Center for Genomics Research, Karolinska Institute, 171 77, Stockholm, Sweden.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AJ271326;  AJ272058;  AJ272059;  AJ272060;  AJ272061
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MeSH Terms
Amino Acid Sequence
Base Sequence
Caenorhabditis elegans / genetics
Caenorhabditis elegans Proteins*
Chromosome Mapping
Chromosomes, Human, Pair 11 / genetics
DNA / genetics
DNA, Complementary / chemistry,  genetics
Genes / genetics*
Helminth Proteins / genetics
In Situ Hybridization, Fluorescence
Membrane Proteins / genetics
Membrane Transport Proteins / genetics*
Molecular Sequence Data
Sequence Alignment
Sequence Analysis, DNA
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/DNA, Complementary; 0/Helminth Proteins; 0/Membrane Proteins; 0/Membrane Transport Proteins; 0/UNC93B1 protein, human; 0/Unc-9 protein, C elegans; 9007-49-2/DNA

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