| hRad21 overexpresses and localizes to the ALT-associated promyelocytic leukemia body in ALT cells. | |
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MedLine Citation:
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PMID: 20364118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Telomerase-negative immortalized cells maintain their telomeres through a telomerase-independent pathway termed alternative lengthening of telomeres (ALT). The mechanism of ALT is based on homologous recombination (HR). A hallmark of ALT cells is presence of a nuclear structure termed ALT-associated promyelocytic leukemia body (APB). Here, we demonstrated that hRAD21, an important subunit of cohesin complex, was overexpressed in ALT cells. We additionally showed that hRAD21 protein localized to APB in ALT cells. Thus, one role of hRAD21 appeared to involve telomere maintenance in ALT cells. We suggested that hRAD21 facilitated telomere HR in ALT cells by participating in APB formation. |
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Authors:
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Bo Zhao; Zhen Jun Wang; Bing Qiang Yi; Hua Chong Ma; Hui Min Xu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-26 |
Journal Detail:
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Title: Cancer biology & therapy Volume: 9 ISSN: 1555-8576 ISO Abbreviation: Cancer Biol. Ther. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-09-21 Completed Date: 2011-02-18 Revised Date: 2011-03-30 |
Medline Journal Info:
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Nlm Unique ID: 101137842 Medline TA: Cancer Biol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 978-83 Citation Subset: IM |
Affiliation:
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Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University, Chaoyang District, Beijing, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle Proteins
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genetics,
metabolism Cell Line Cell Line, Tumor Chromosomal Proteins, Non-Histone / genetics, metabolism DNA Repair Gene Expression Humans Intranuclear Inclusion Bodies / metabolism* Multiprotein Complexes / metabolism Nuclear Proteins / genetics, metabolism* Phosphoproteins / genetics, metabolism* Recombination, Genetic* Telomerase / genetics, metabolism Telomere / genetics, metabolism* Telomeric Repeat Binding Protein 2 / genetics, metabolism Transcription Factors / metabolism Tumor Suppressor Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Chromosomal Proteins, Non-Histone; 0/Multiprotein Complexes; 0/Nuclear Proteins; 0/Phosphoproteins; 0/RAD21 protein, human; 0/Telomeric Repeat Binding Protein 2; 0/Transcription Factors; 0/Tumor Suppressor Proteins; 0/cohesins; 143220-95-5/PML protein, human; EC 2.7.7.49/Telomerase |
| Comments/Corrections | |
Comment In:
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Cancer Biol Ther. 2010 Jun;9(12):984-5
[PMID:
20431348
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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