| hP, the component of log P controlling structure-activity relationships amongst non-steroidal anti-inflammatory drugs. | |
| | |
MedLine Citation:
|
PMID: 8737045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A range of 25 drugs and other compounds selected from published sources by strict criteria, has been used to confirm that their ability to inhibit the production of prostaglandin by mouse peritoneal macrophage does not correlate with log P but with hP, the parameter composed of only the hydrophobic contributions (atoms and groups composed of carbon, hydrogen and halogens). Other heteroatoms and physical properties can usually be ignored. Anti-inflammatory activity does not depend upon pKa or partition phenomena unless extreme, nor does it depend primarily upon the structural types within the range phenols, salicylic acids, mefenamic acids, areneacetic and profenic acids. |
| | |
Authors:
|
F M Dean |
Related Documents
:
|
133645 - Analgesic and anti-inflammatory activity of 6-chloro-alpha-methyl-carbazole-2-acetic ac... 10399025 - Synthesis and anti-phlogistic potency of some new non-proteinogenic amino acid conjugat... 21710975 - Arabidopsis nip7;1: an anther-specific boric acid transporter of the aquaporin superfam... 12465805 - Detection of tannic acid at trace level in industrial wastewaters using a highly sensit... 12162555 - Cloning, characterization, and expression of cdna encoding a lipase from kurtzmanomyces... 16660705 - Kinetics of l-alanine escape from xylem vessels. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: The Journal of pharmacy and pharmacology Volume: 48 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1996 Mar |
Date Detail:
|
Created Date: 1997-01-29 Completed Date: 1997-01-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 233-9 Citation Subset: IM |
Affiliation:
|
Department of Chemistry, University of Liverpool, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anti-Inflammatory Agents, Non-Steroidal / chemistry*, pharmacology* Cyclooxygenase Inhibitors / chemistry, pharmacology Macrophages, Peritoneal / drug effects*, metabolism Mice Regression Analysis Solubility Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Immunohistochemical detection of immature Sertoli cell markers in testicular tissue of infertile adu...
Next Document: Correlation of pharmacological properties of a group of hypolipaemic drugs by molecular topology.