Document Detail

hDAF porcine cardiac xenograft maintains cardiac output after orthotopic transplantation into baboon--a perioperative study.
MedLine Citation:
PMID:  16202067     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Only limited data are available on the physiological functional compatibility of cardiac xenografts after orthotopic pig to baboon transplantation (oXHTx). Thus we investigated hemodynamic parameters including cardiac output (CO) before and after oXHTx. METHODS: Orthotopic xenogeneic heart transplantation from nine hDAF transgeneic piglets to baboons was performed. We used femoral arterial thermodilution for the invasive assessment of CO and stroke volume. RESULTS: Baseline CO of the baboons after induction of anesthesia was 1.36 (1.0-1.9) l/min. 30 to 60 min after termination of the cardiopulmonary bypass, CO of the cardiac xenograft was significantly increased to 1.72 (1.3-2.1) l/min (P < 0.01). The stroke volumes of the baboon heart before transplantation and the cardiac xenograft was comparable [14.9 (11-26) vs. 11.8 (10-23) ml]. Thus the higher CO was achieved by an increase in heart rate after oXHTx [75.0 (69-110) vs. 140.0 (77-180)/min; P < 0.01]. Despite the increased CO, oxygen delivery was reduced [256 (251-354) vs. 227 (172-477) ml/min; P < 0.01] due to the inevitable hemodilution during the cardiopulmonary bypass and the blood loss caused by the surgical procedures. CONCLUSION: Our results demonstrate that in the early phase after orthotopic transplantation of hDAF pig hearts to baboons, cardiac function of the donor heart is maintained and exceeds baseline CO. However, in the early intraoperative phase this was only possible by using inotropic substances and vasopressors due to the inevitable blood loss and dilution by the priming of the bypass circuit.
Andreas Bauer; Heiko Baschnegger; Jan M Abicht; Ulrike Brandl; Paolo Brenner; Eckart Thein; Claus Hammer; Bruno Reichart; Klaus Peter; Michael Schmoeckel; Frank Christ
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Xenotransplantation     Volume:  12     ISSN:  0908-665X     ISO Abbreviation:  Xenotransplantation     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-05     Completed Date:  2005-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9438793     Medline TA:  Xenotransplantation     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  444-9     Citation Subset:  IM    
Clinic for Anaesthesiology, Ludwig-Maximilians University Munich, Munich, Germany.
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MeSH Terms
Animals, Genetically Modified
Antigens, CD55 / genetics*,  metabolism*
Cardiac Output / physiology*
Heart Transplantation*
Transgenes / genetics
Transplantation, Heterologous
Reg. No./Substance:
0/Antigens, CD55

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