| hCG and hCG subunits as tumour markers in patients with endocrine pancreatic tumours and carcinoids. | |
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MedLine Citation:
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PMID: 6117168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum levels of hCG, hCG-alpha- and hCG-beta-subunits were measured in 29 patients with APUD-tumours, 16 patients with endocrine pancreatic tumours (EPT) and 13 patients with carcinoids. Twenty out of 29 patients (69%) had elevated level of hCG and its subunits. Among patients with EPT, 11 out of 16 (69%) had raised levels of these peptides. Three patients with benign tumours had normal concentrations, thus giving a frequency of 85% in the group of malignant EPT. In patients with carcinoids 9 out of 13 (69%) had elevated serum levels of at least one of the components. A discordance in secretion pattern between the two types of APUD-tumours was noticed. Only one patient, a case with a carcinoid had raised levels of the complete hCG molecule. The levels of hCG-alpha were elevated in 23% of the patients with malignant EPT and 69% of the patients with carcinoids while the corresponding frequencies of raised hCG-beta levels were 69% and 8%, respectively. Three out of 4 patients with so-called non-functioning islet cell tumours had raised levels of the subunits. These results indicate that hCG subunits are valuable tumour markers in both of these APUD-tumours, and that malignant EPT predominantly secrete hCG-beta- and carcinoids hCG-alpha-subunits. |
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Authors:
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K Oberg; L Wide |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta endocrinologica Volume: 98 ISSN: 0001-5598 ISO Abbreviation: Acta Endocrinol. Publication Date: 1981 Oct |
Date Detail:
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Created Date: 1981-12-15 Completed Date: 1981-12-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370312 Medline TA: Acta Endocrinol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 256-60 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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APUD Cells Adenoma, Islet Cell / blood*, secretion Adult Aged Calcitonin / secretion Carcinoid Tumor / blood* Chorionic Gonadotropin / blood* Female Humans Insulinoma / blood Lung Neoplasms / blood Male Middle Aged Pancreatic Neoplasms / blood*, secretion Vipoma / blood Zollinger-Ellison Syndrome / blood |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 9007-12-9/Calcitonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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