Document Detail


hCG and hCG subunits as tumour markers in patients with endocrine pancreatic tumours and carcinoids.
MedLine Citation:
PMID:  6117168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum levels of hCG, hCG-alpha- and hCG-beta-subunits were measured in 29 patients with APUD-tumours, 16 patients with endocrine pancreatic tumours (EPT) and 13 patients with carcinoids. Twenty out of 29 patients (69%) had elevated level of hCG and its subunits. Among patients with EPT, 11 out of 16 (69%) had raised levels of these peptides. Three patients with benign tumours had normal concentrations, thus giving a frequency of 85% in the group of malignant EPT. In patients with carcinoids 9 out of 13 (69%) had elevated serum levels of at least one of the components. A discordance in secretion pattern between the two types of APUD-tumours was noticed. Only one patient, a case with a carcinoid had raised levels of the complete hCG molecule. The levels of hCG-alpha were elevated in 23% of the patients with malignant EPT and 69% of the patients with carcinoids while the corresponding frequencies of raised hCG-beta levels were 69% and 8%, respectively. Three out of 4 patients with so-called non-functioning islet cell tumours had raised levels of the subunits. These results indicate that hCG subunits are valuable tumour markers in both of these APUD-tumours, and that malignant EPT predominantly secrete hCG-beta- and carcinoids hCG-alpha-subunits.
Authors:
K Oberg; L Wide
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta endocrinologica     Volume:  98     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1981-12-15     Completed Date:  1981-12-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  256-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
APUD Cells
Adenoma, Islet Cell / blood*,  secretion
Adult
Aged
Calcitonin / secretion
Carcinoid Tumor / blood*
Chorionic Gonadotropin / blood*
Female
Humans
Insulinoma / blood
Lung Neoplasms / blood
Male
Middle Aged
Pancreatic Neoplasms / blood*,  secretion
Vipoma / blood
Zollinger-Ellison Syndrome / blood
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 9007-12-9/Calcitonin

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