Document Detail

The gut endocrine system as a coordinator of postprandial nutrient homoeostasis.
MedLine Citation:
PMID:  22906726     Owner:  NLM     Status:  MEDLINE    
Hormones from the gastrointestinal (GI) tract are released following food ingestion and trigger a range of physiological responses including the coordination of appetite and glucose homoeostasis. The aim of this review is to discuss the pathways by which food ingestion triggers secretion of cholecystokinin (CCK), glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) and the altered patterns of gut hormone release observed following gastric bypass surgery. Our understanding of how ingested nutrients trigger secretion of these gut hormones has increased dramatically, as a result of physiological studies in human subjects and animal models and in vitro studies on cell lines and primary intestinal cultures. Specialised enteroendocrine cells located within the gut epithelium are capable of directly detecting a range of nutrient stimuli through a range of receptors and transporters. It is concluded that the arrival of nutrients at the apical surface of enteroendocrine cells is a major stimulus for gut hormone release, thereby coupling these endocrine signals to the arrival of absorbed nutrients in the bloodstream.
Fiona M Gribble
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-08-21
Journal Detail:
Title:  The Proceedings of the Nutrition Society     Volume:  71     ISSN:  1475-2719     ISO Abbreviation:  Proc Nutr Soc     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-26     Completed Date:  2013-04-04     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  7505881     Medline TA:  Proc Nutr Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  456-62     Citation Subset:  IM    
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MeSH Terms
Cholecystokinin / secretion*
Diabetes Mellitus, Type 2 / metabolism
Eating / physiology*
Enteroendocrine Cells / metabolism*
Gastrointestinal Tract / metabolism*
Glucagon-Like Peptide 1 / secretion*
Obesity / metabolism,  surgery
Postprandial Period
Receptors, Gastrointestinal Hormone / metabolism*
Signal Transduction
Grant Support
088357//Wellcome Trust; WT088357//Wellcome Trust
Reg. No./Substance:
0/Receptors, Gastrointestinal Hormone; 0/gastric inhibitory polypeptide receptor; 89750-14-1/Glucagon-Like Peptide 1; 9011-97-6/Cholecystokinin

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