| The guinea pig as an animal model for studying perinatal changes in microvascular function. | |
| | |
MedLine Citation:
|
PMID: 22289846 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Introduction:Microvascular dysfunction, characterized by inappropriate vasodilatation and high blood flow in the peripheral microcirculation, is linked to physiologic instability and poor outcome in neonates. Specifically, preterm neonates have significantly higher levels of baseline microvascular blood flow than term neonates at 24 h postnatal age. Because of similarities between human and guinea pig endocrine profiles and maturity at birth, we hypothesized that preterm guinea pig neonates would provide a suitable model for studying the mechanisms underlying transitional microvascular function.Results:Guinea pigs that were delivered preterm showed immaturity and had markedly reduced viability. Baseline microvascular blood flow was significantly higher in preterm animals than in term animals. No effect of intrauterine growth restriction or birth weight on baseline microvascular blood flow was observed in either preterm or term animals.Discussion:These results are consistent with recent clinical findings and support the use of the guinea pig as a suitable model for future studies of the mechanisms underlying perinatal microvascular behavior.Methods:Guinea pigs were delivered either prematurely or at term. Laser Doppler flowmetry was used to study microvascular blood flow at 23 h postnatal age. |
| | |
Authors:
|
Rebecca M Dyson; Hannah K Palliser; Meredith A Kelleher; Jonathan J Hirst; Ian M R Wright |
Related Documents
:
|
2303836 - The blood/cerebrospinal fluid partitioning of pyrazinamide: a study during the course o... 3085446 - Acute subdural hematomas: atypical ct findings. 1282446 - Patterns of primary degranulation as indicated by the mean myeloperoxidase index (mpxi)... 6658906 - Oxypurines in cerebrospinal fluid as indices of disturbed brain metabolism. a clinical ... 12665996 - Effects of the flow waveform method of triggering and cycling on patient-ventilator int... 1607646 - Poor reliability of immunocytochemical localization of igg in immersion-fixed tissue fr... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pediatric research Volume: 71 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
|
Languages: eng Pagination: 20-4 Citation Subset: IM |
Affiliation:
|
1] Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, Australia [2] Discipline of Paediatrics and Child Health, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ontogeny of angiotensin-converting enzyme 2.
Next Document: Chronic hypoxia increases peroxynitrite, MMP9 expression, and collagen accumulation in fetal guinea ...