| On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes. | |
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MedLine Citation:
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PMID: 20179091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The regulation of body axis specification in the common ancestor of bilaterians remains controversial. BMP signaling appears to be an ancient program for patterning the secondary, or dorsoventral, body axis, but any such program for the primary, or anteroposterior, body axis is debated. Recent work in invertebrates indicates that posterior Wnt/beta-catenin signaling is such a mechanism and that it evolutionarily predates the cnidarian-bilaterian split. Here, I argue that a Cartesian coordinate system of positional information set up by gradients of perpendicular Wnt and BMP signaling is conserved in bilaterians, orchestrates body axis patterning and contributes to both the relative invariance and diversity of body forms. |
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Authors:
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Christof Niehrs |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 137 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-24 Completed Date: 2010-04-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 845-57 Citation Subset: IM |
Affiliation:
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Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. Niehrs@DKFZ-Heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Patterning / physiology* Bone Morphogenetic Proteins / metabolism, physiology* Chordata, Nonvertebrate / anatomy & histology, embryology, genetics, physiology Cnidaria / anatomy & histology, embryology, genetics, physiology Embryo, Nonmammalian Evolution, Molecular Gene Expression Regulation, Developmental Growth and Development / physiology* Models, Biological Models, Theoretical Phylogeny Signal Transduction / physiology Wnt Proteins / metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Bone Morphogenetic Proteins; 0/Wnt Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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