Document Detail

The growth of the canine glioblastoma cell line D-GBM and the canine histiocytic sarcoma cell line DH82 is inhibited by the resveratrol oligomers hopeaphenol and r2-viniferin.
MedLine Citation:
PMID:  22882564     Owner:  NLM     Status:  Publisher    
Vineatrol(®) 30 is a grapevine-shoot extract, which contains resveratrol as well as considerable amounts of so-called resveratrol oligomers such as hopeaphenol and r2-viniferin. In this study, we analysed whether the two above-mentioned resveratrol oligomers were able to inhibit the growth of the canine glioblastoma cell line D-GBM and the canine histiocytic sarcoma cell line DH82, compared their potency to inhibit tumour cell growth with that of resveratrol and determined whether the induction of apoptosis via caspase 9 and 3/7 activation underlies the tumour cell growth-inhibiting effect of hopeaphenol and r2-viniferin. Vineatrol(®) 30, resveratrol, hopeaphenol and r2-viniferin inhibited the growth of D-GBM and DH82 cells in a concentration-dependent manner, whereby hopeaphenol and r2-viniferin were more potent than resveratrol itself in inhibiting the growth of the canine tumour cell lines. Moreover, the anti-proliferative effect of both resveratrol oligomers in D-GBM cells is based on their capacity to induce caspase 9 and 3/7 activation.
M T Empl; S Macke; P Winterhalter; C Puff; S Lapp; G Stoica; W Baumgärtner; P Steinberg
Related Documents :
17356234 - Structural differences between sensitive and resistant l1210 cells.
21212934 - Difference in the biological effects of clostridium difficile toxin b in proliferating ...
22391574 - Sunitinib targets pdgf-receptor and flt3 and reduces survival and migration of human me...
21526234 - Okadaic acid induces morphological changes, apoptosis and cell cycle alterations in dif...
14572164 - Leukemia-lymphoma cell lines as model systems for hematopoietic research.
15671064 - Rnai of face1 protease results in growth inhibition of human cells expressing lamin a: ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-10
Journal Detail:
Title:  Veterinary and comparative oncology     Volume:  9999     ISSN:  1476-5829     ISO Abbreviation:  Vet Comp Oncol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101185242     Medline TA:  Vet Comp Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Institute for Food Toxicology and Analytical Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Associations between health insurance and generalized periodontal disease in a study population of G...
Next Document:  Tight junction properties change during epidermis development.