Document Detail


The growing volume of diabetes-related dialysis: a population based study.
MedLine Citation:
PMID:  15507475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: End-stage renal failure requiring dialysis is one of the most serious complications of diabetes mellitus, and diabetes is the most common cause of end-stage renal failure. The aim of this large, observational study is to describe the population-based incidence and prevalence rates and outcomes of diabetic individuals in Ontario, Canada who require dialysis therapy. METHODS: Two cohorts of patients, those with diabetes and those without, were created between April 1, 1994 and March 31, 2000 (total of approximately 8.4 million) and followed until March 31, 2001 using several large, linked administrative databases at the Institute for Clinical Evaluative Sciences. The incidence, prevalence and mortality on dialysis for each cohort were determined. A multivariate Cox proportional hazards analysis, adjusting for age, sex and co-morbidity, was used to determine the independent impact of diabetes on patient survival. RESULTS: The average annual incidence rate of dialysis was 12 times greater in persons with diabetes (130 per 100,000) vs without diabetes (11 per 100,000). By 1999-2000, diabetic patients comprised 51% of the incident dialysis population. The average annual prevalence rate was 10 times greater in the diabetic cohort. Patients with diabetes had more co-morbidities at the start of dialysis and poorer 3 year survival (55 vs 68%; P < 0.0001). CONCLUSIONS: The incident and prevalent rates of dialysis for patients with diabetes mellitus are many times the rates of those without diabetes. Patients with diabetes mellitus often start dialysis with significant co-morbidities, which may contribute to the relatively high rate of mortality on dialysis.
Authors:
Charmaine E Lok; Matthew J Oliver; Deanna M Rothwell; Janet E Hux
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2004-10-26
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  19     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-02     Completed Date:  2005-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  3098-103     Citation Subset:  IM    
Affiliation:
Division of Nephrology, University Health Network, Toronto General Hospital, Canada. charmaine.lok@uhn.on.ca
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MeSH Terms
Descriptor/Qualifier:
Cohort Studies
Comorbidity
Diabetic Nephropathies / therapy*
Humans
Kidney Failure, Chronic / therapy*
Prevalence
Renal Replacement Therapy / mortality,  statistics & numerical data*
Survival Analysis
United States

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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