| The great cholesterol myth; unfortunate consequences of Brown and Goldstein's mistake. | |
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MedLine Citation:
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PMID: 21690178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Following their Nobel Prize-winning discovery of the defective gene causing familial hypercholesterolaemia, Brown and Goldstein misunderstood the mechanism involved in the pathogenesis of the associated arterial disease. They ascribed this to an effect of the high levels of cholesterol circulating in the blood. In reality, the accelerated arterial damage is likely to be a consequence of more brittle arterial cell walls, as biochemists know cholesterol to be a component of them which modulates their fluidity, conferring flexibility and hence resistance to damage from the ordinary hydrodynamic blood forces. In the absence of efficient receptors for LDL cholesterol, cells will be unable to use this component adequately for the manufacture of normally resilient arterial cell walls, resulting in accelerated arteriosclerosis. Eating cholesterol is harmless, shown by its failure to produce vascular accidents in laboratory animals, but its avoidance causes human malnutrition from lack of fat-soluble vitamins, especially vitamin D. |
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Authors:
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D D Adams |
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Publication Detail:
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Type: Journal Article Date: 2011-06-20 |
Journal Detail:
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Title: QJM : monthly journal of the Association of Physicians Volume: 104 ISSN: 1460-2393 ISO Abbreviation: QJM Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-28 Completed Date: 2012-03-15 Revised Date: 2012-04-03 |
Medline Journal Info:
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Nlm Unique ID: 9438285 Medline TA: QJM Country: England |
Other Details:
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Languages: eng Pagination: 867-70 Citation Subset: IM |
Affiliation:
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Faculty of Medicine, University of Otago, P.O. Box 913, Dunedin, New Zealand. duncan.adams@stonebow.otago.ac.nz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / physiopathology Arteriosclerosis / blood, etiology*, physiopathology Cholesterol / blood Cholesterol, Dietary / adverse effects* Disease Models, Animal Evidence-Based Medicine Humans Hyperlipoproteinemia Type II / blood, complications*, genetics Mythology |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, Dietary; 57-88-5/Cholesterol |
| Comments/Corrections | |
Comment In:
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QJM. 2012 Mar;105(3):291-2; author reply 292
[PMID:
22187507
]
QJM. 2012 Feb;105(2):214 [PMID: 22109684 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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