Document Detail

The great GATC: DNA methylation in E. coli.
MedLine Citation:
PMID:  2667217     Owner:  NLM     Status:  MEDLINE    
In Escherichia coli the methylation of the adenine in the sequence 5'-GATC-3' is catalysed by the dam gene product, a DNA adenine methylase. We review the proposed roles for this methylation, and the sequence it modifies, in mismatch repair, DNA-protein interaction, gene expression, the initiation of chromosome replication, chromosome segregation, chromosome structure and the occurrence of mutational hotspots.
F Barras; M G Marinus
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Trends in genetics : TIG     Volume:  5     ISSN:  0168-9525     ISO Abbreviation:  Trends Genet.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-08-29     Completed Date:  1989-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8507085     Medline TA:  Trends Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  139-43     Citation Subset:  IM    
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MeSH Terms
Base Sequence
Chromosomes, Bacterial
DNA Modification Methylases / metabolism*
DNA Replication
DNA, Bacterial / genetics,  metabolism*
Escherichia coli / genetics*
Gene Expression Regulation
Reg. No./Substance:
0/DNA, Bacterial; EC 2.1.1.-/DNA Modification Methylases

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