Document Detail


A graded association of exercise capacity and all-cause mortality in males with high-normal blood pressure.
MedLine Citation:
PMID:  19919397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Information regarding the effect of exercise capacity on mortality risk in individuals with high-normal blood pressure is severely limited. Thus, we evaluated the association of exercise capacity and all-cause mortality in individuals with high-normal blood pressure. METHODS: Exercise test was performed in 1727 males with high-normal blood pressure at two Veteran sites (Washington, DC, and Palo Alto, CA). Fitness status was assessed in metabolic equivalents (METs) at exercise peak. All-cause mortality was recorded for a mean follow-up period of 9.8+/-6.0 years. RESULTS: Exercise capacity was inversely associated with all-cause mortality, and the association was independent of traditional cardiovascular risk factors. For each 1 MET increase in exercise capacity, the adjusted mortality risk was reduced by 13%, underscoring the strong predictive value of exercise capacity that was confirmed by ROC analysis. Data analysis according to fitness levels revealed a threshold level of 4 METs, over which the mortality risk was progressively reduced by 30% (hazard ratio=0.70; CI 0.51-0.95) for those who achieved 4.1-6.0 METs and 61% (hazard ratio=0.39; CI 0.26-0.57) for those who achieved 8.1-10 METs. No additional reductions in risk were noted until the MET level achieved exceeded 12 METs. CONCLUSIONS: We observed a strong, inverse, graded and independent association between exercise capacity and all-cause mortality in individuals with high-normal blood pressure. Our findings indicate that a shift of the fitness curve to the right is associated with significant survival benefits, and even slight differences in fitness levels are associated with substantial reductions in mortality risk.
Authors:
Peter Kokkinos; Michael Doumas; Jonathan Myers; Charles Faselis; Athanasios Manolis; Andreas Pittaras; John Peter Kokkinos; Vasilios Papademetriou; Steven Singh; Ross D Fletcher
Related Documents :
10549047 - Perceptions of physical fitness in patients with heart failure.
20813077 - The more physical inactivity, the more agitation in dementia.
19652447 - Positive effects of acute and moderate physical exercise on cognitive function.
8007797 - Exercise-induced diarrhea: when to wonder.
22894977 - Effects of calisthenics and pilates exercises on coordination and proprioception in adu...
7520887 - Glial hypertrophy is associated with synaptogenesis following motor-skill learning, but...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood pressure     Volume:  18     ISSN:  1651-1999     ISO Abbreviation:  Blood Press.     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  England    
Other Details:
Languages:  eng     Pagination:  261-7     Citation Subset:  IM    
Affiliation:
Veterans Affairs Medical Center, Washington, DC 20422, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Blood Pressure / physiology*
Exercise Test
Exercise Tolerance / physiology*
Humans
Hypertension / mortality*,  physiopathology
Male
Middle Aged
Mortality
Physical Fitness
Predictive Value of Tests
Retrospective Studies
Risk Factors
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acute effects of pharmacotherapies in blood pressure in normotensive moderate smokers.
Next Document:  Association between hyperuricemia and hypertension in a Chinese population at a high risk of hyperte...