| A graded association of exercise capacity and all-cause mortality in males with high-normal blood pressure. | |
| | |
MedLine Citation:
|
PMID: 19746293 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Introduction. Information regarding the effect of exercise capacity on mortality risk in individuals with high-normal blood pressure is severely limited. Thus, we evaluated the association of exercise capacity and all-cause mortality in individuals with high-normal blood pressure. Methods. Exercise test was performed in 1727 males with high-normal blood pressure at two Veteran sites (Washington, DC, and Palo Alto, CA). Fitness status was assessed in metabolic equivalents (METs) at exercise peak. All-cause mortality was recorded for a mean follow-up period of 9.8+/-6.0 years. Results. Exercise capacity was inversely associated with all-cause mortality, and the association was independent of traditional cardiovascular risk factors. For each 1 MET increase in exercise capacity, the adjusted mortality risk was reduced by 13%, underscoring the strong predictive value of exercise capacity that was confirmed by ROC analysis. Data analysis according to fitness levels revealed a threshold level of 4 METs, over which the mortality risk was progressively reduced by 30% (hazard ratio=0.70; CI 0.51-0.95) for those who achieved 4.1-6.0 METs and 61% (hazard ratio=0.39; CI 0.26-0.57) for those who achieved 8.1-10 METs. No additional reductions in risk were noted until the MET level achieved exceeded 12 METs. Conclusions. We observed a strong, inverse, graded and independent association between exercise capacity and all-cause mortality in individuals with high-normal blood pressure. Our findings indicate that a shift of the fitness curve to the right is associated with significant survival benefits, and even slight differences in fitness levels are associated with substantial reductions in mortality risk. |
| | |
Authors:
|
Peter Kokkinos; Michael Doumas; Jonathan Myers; Charles Faselis; Athanasios Manolis; Andreas Pittaras; John Peter Kokkinos; Vasilios Papademetriou; Steven Singh; Ross D Fletcher |
Related Documents
:
|
21496083 - Effects of two training protocols on angiotensin i-converting enzyme (ace) activity in ... 17351693 - Analysing the favourable effects of physical exercise: relationships between physical f... 23216343 - Effects of exercise training on nitric oxide synthase in the kidney of spontaneously hy... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2009-9-10 |
Journal Detail:
|
Title: Blood pressure Volume: - ISSN: 1651-1999 ISO Abbreviation: Blood Press. Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-9-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9301454 Medline TA: Blood Press Country: - |
Other Details:
|
Languages: ENG Pagination: 1-7 Citation Subset: - |
Affiliation:
|
Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Forensic reports
Next Document: Effect of device-guided breathing exercises on blood pressure in patients with hypertension: