Document Detail


The gp 130 family cytokines IL-6, LIF and OSM but not IL-11 can reverse the anti-proliferative effect of dexamethasone on human myeloma cells.
MedLine Citation:
PMID:  7647014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to understand the mechanisms supporting steroid escape in patients with multiple myeloma (MM), three IL-6 autocrine human myeloma cell lines, LP1, OPM2 and L363, have been treated with dexamethasone in the presence or absence of cytokines belonging to the gp 130 family: IL-6, LIF, OSM and IL-11. With pharmacological doses of dexamethasone, a dramatic growth arrest was observed in all the cell lines. IL-6 completely reversed this inhibition. Of note, this IL-6 induced reversion was still seen with very low amounts of IL-6 (12 pg/ml). Finally, whereas LIF and OSM had clear growth-promoting effects on OPM2 only, both cytokines (but not IL-11) reversed the dexamethasone-induced growth arrest in all the cell lines. Therefore the high levels of IL-6 (ng/ml) observed in the MM intermediate milieu and the putative presence of LIF and OSM can easily counteract the effects of dexamethasone in vivo.
Authors:
N Juge-Morineau; S François; D Puthier; A Godard; R Bataille; M Amiot
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  90     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-09-25     Completed Date:  1995-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  707-10     Citation Subset:  IM    
Affiliation:
Laboratoire d'Oncogénèse Immunohématologique, Inserm U211, Nantes, France.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology*
Cell Division / drug effects
Dexamethasone / pharmacology*
Growth Inhibitors / pharmacology*
Humans
Interleukin-11 / pharmacology*
Interleukin-6 / pharmacology*
Leukemia Inhibitory Factor
Lymphokines / pharmacology*
Multiple Myeloma / pathology*
Oncostatin M
Peptides / pharmacology*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Growth Inhibitors; 0/Interleukin-11; 0/Interleukin-6; 0/LIF protein, human; 0/Leukemia Inhibitory Factor; 0/Lymphokines; 0/OSM protein, human; 0/Peptides; 106956-32-5/Oncostatin M; 50-02-2/Dexamethasone

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