Document Detail

The gp 130 family cytokines IL-6, LIF and OSM but not IL-11 can reverse the anti-proliferative effect of dexamethasone on human myeloma cells.
MedLine Citation:
PMID:  7647014     Owner:  NLM     Status:  MEDLINE    
In order to understand the mechanisms supporting steroid escape in patients with multiple myeloma (MM), three IL-6 autocrine human myeloma cell lines, LP1, OPM2 and L363, have been treated with dexamethasone in the presence or absence of cytokines belonging to the gp 130 family: IL-6, LIF, OSM and IL-11. With pharmacological doses of dexamethasone, a dramatic growth arrest was observed in all the cell lines. IL-6 completely reversed this inhibition. Of note, this IL-6 induced reversion was still seen with very low amounts of IL-6 (12 pg/ml). Finally, whereas LIF and OSM had clear growth-promoting effects on OPM2 only, both cytokines (but not IL-11) reversed the dexamethasone-induced growth arrest in all the cell lines. Therefore the high levels of IL-6 (ng/ml) observed in the MM intermediate milieu and the putative presence of LIF and OSM can easily counteract the effects of dexamethasone in vivo.
N Juge-Morineau; S François; D Puthier; A Godard; R Bataille; M Amiot
Related Documents :
15255954 - Beta-naphthoflavone disturbs astrocytic differentiation of c6 glioma cells by inhibitin...
22318424 - An update on the pathogenesis and treatment of iga nephropathy.
11295404 - Secretion of cytokines by uroepithelial cells stimulated by escherichia coli and citrob...
14726234 - Pharmacological inhibition of mannheimia haemolytica lipopolysaccharide and leukotoxin-...
20192954 - Interferon-gamma inhibits metalloproteinase activity and cytotrophoblast cell migration.
24191234 - A role for mitochondrial oxidants in stress-induced premature senescence of human vascu...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  90     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-09-25     Completed Date:  1995-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  707-10     Citation Subset:  IM    
Laboratoire d'Oncogénèse Immunohématologique, Inserm U211, Nantes, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antineoplastic Agents / pharmacology*
Cell Division / drug effects
Dexamethasone / pharmacology*
Growth Inhibitors / pharmacology*
Interleukin-11 / pharmacology*
Interleukin-6 / pharmacology*
Leukemia Inhibitory Factor
Lymphokines / pharmacology*
Multiple Myeloma / pathology*
Oncostatin M
Peptides / pharmacology*
Tumor Cells, Cultured
Reg. No./Substance:
0/Antineoplastic Agents; 0/Growth Inhibitors; 0/Interleukin-11; 0/Interleukin-6; 0/LIF protein, human; 0/Leukemia Inhibitory Factor; 0/Lymphokines; 0/OSM protein, human; 0/Peptides; 106956-32-5/Oncostatin M; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Combined immunophenotyping and in situ hybridization (FICTION): a rapid method to study cell lineage...
Next Document:  Growth inhibition of leukaemic cells carrying the t(3;21) by the AML1/EVI-1-specific antisense oligo...