Document Detail

A goodness-of-fit test for the polygenic threshold model: application to multiple sclerosis.
MedLine Citation:
PMID:  7234906     Owner:  NLM     Status:  MEDLINE    
Recently it has been suggested that multiple sclerosis may be a multifactorial disorder. We found in British Columbia 364 families (sibship size greater than or equal to 2) in which at least on sibling was diagnosed as having "clinically definite" multiple sclerosis. The data were tested for goodness-of-fit to the multifactorial model using an analysis that considers various parameters including ascertainment probability heritability, and sex-dependent prevalence rates. The results suggest that multiple sclerosis does not fit the multifactorial model. As an alternative genetic model we propose that a major gene could be responsible for at least a portion of the cases of multiple sclerosis.
A D Sadovnick; M A Spence; S Tideman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of medical genetics     Volume:  8     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  1981  
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  355-61     Citation Subset:  IM    
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MeSH Terms
Models, Genetic*
Multiple Sclerosis / genetics*
Selection, Genetic
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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