| A gonadotropin releasing hormone analogue prevents cyclical attacks of porphyria. | |
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MedLine Citation:
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PMID: 2196028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute intermittent porphyria is a genetic disease in which endogenous hormones affect clinical expression. Premenstrual exacerbations can occur, sometimes often, in women with this disease. Gonadotropin releasing hormone analogues can prevent ovulation by reducing secretion of luteinizing hormone and follicle-stimulating hormone. In six patients with well-documented acute intermittent porphyria and frequent cyclical exacerbations, daily administration of an agonistic gonadotropin releasing hormone analogue, ([ImBzl]-D-His6,Pro9-NET)gonadotropin releasing hormone, intranasally or subcutaneously for as long as 26 months reduced or eliminated premenstrual attacks and caused only minor side effects. Adjustments in dosage or route of administration were sometimes needed. We conclude that endocrine manipulation by treatment with a gonadotropin releasing hormone agonist will prevent neurovisceral attacks of acute intermittent porphyria due to cyclical changes in endogenous hormones and is a safe alternative to exogenous steroids, which may induce attacks of this disease. |
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Authors:
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K E Anderson; I M Spitz; C W Bardin; A Kappas |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of internal medicine Volume: 150 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-08-13 Completed Date: 1990-08-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1469-74 Citation Subset: AIM; IM |
Affiliation:
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Rockefeller University Hospital, New York, NY. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aminolevulinic Acid / urine Female Gonadotropin-Releasing Hormone / adverse effects, analogs & derivatives*, therapeutic use Humans Menstrual Cycle / physiology Periodicity Porphobilinogen / urine Porphyrias / physiopathology, prevention & control*, urine |
| Grant Support | |
ID/Acronym/Agency:
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AM-32890/AM/NIADDK NIH HHS; ES-01055/ES/NIEHS NIH HHS; FD-R-000307/FD/FDA HHS |
| Chemical | |
Reg. No./Substance:
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106-60-5/Aminolevulinic Acid; 33515-09-2/Gonadotropin-Releasing Hormone; 487-90-1/Porphobilinogen; 76712-82-8/histrelin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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