Document Detail

The 'gold standard' for optimal fetal growth and development.
MedLine Citation:
PMID:  11837507     Owner:  NLM     Status:  MEDLINE    
It is now becoming accepted that birth size per se is too crude an outcome measure to be used for the assessment of optimal intrauterine growth and development, and that a new vision of optimal fetal development is required for the 21st century. This will need to take account of both short- and long-term outcomes, to recognize that maternal body composition and diet can have long-term effects without necessarily affecting size at birth, and to take account of important interactions between the pre- and postnatal environments. At present, our understanding is limited and new definitions should only be considered as working hypotheses. Nonetheless, it is possible to begin to set out a framework for defining optimal fetal growth and development. This acknowledges the importance of developmental adaptations to alterations in the nutrient and hormonal milieu in utero and could have a major impact on human health in the century to come.
K M Godfrey
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  14 Suppl 6     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2001  
Date Detail:
Created Date:  2002-02-11     Completed Date:  2002-07-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  1507-13     Citation Subset:  IM    
MRC Environmental Epidemiology Unit (University of Southampton), Southampton General Hospital, UK.
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MeSH Terms
Embryonic and Fetal Development
Fetal Growth Retardation / physiopathology
Fetus / physiology*
Growth Hormone / physiology
Growth Substances / physiology
Nutritional Physiological Phenomena
Reg. No./Substance:
0/Growth Substances; 9002-72-6/Growth Hormone

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