Document Detail


The 'gold standard' for optimal fetal growth and development.
MedLine Citation:
PMID:  11837507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is now becoming accepted that birth size per se is too crude an outcome measure to be used for the assessment of optimal intrauterine growth and development, and that a new vision of optimal fetal development is required for the 21st century. This will need to take account of both short- and long-term outcomes, to recognize that maternal body composition and diet can have long-term effects without necessarily affecting size at birth, and to take account of important interactions between the pre- and postnatal environments. At present, our understanding is limited and new definitions should only be considered as working hypotheses. Nonetheless, it is possible to begin to set out a framework for defining optimal fetal growth and development. This acknowledges the importance of developmental adaptations to alterations in the nutrient and hormonal milieu in utero and could have a major impact on human health in the century to come.
Authors:
K M Godfrey
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  14 Suppl 6     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2001  
Date Detail:
Created Date:  2002-02-11     Completed Date:  2002-07-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  1507-13     Citation Subset:  IM    
Affiliation:
MRC Environmental Epidemiology Unit (University of Southampton), Southampton General Hospital, UK. kmg@mrc.soton.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Embryonic and Fetal Development
Fetal Growth Retardation / physiopathology
Fetus / physiology*
Growth Hormone / physiology
Growth Substances / physiology
Humans
Nutritional Physiological Phenomena
Chemical
Reg. No./Substance:
0/Growth Substances; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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