Document Detail

A goitrogenic agent from millet (Pennisetum typhoides) in Darfur Province, Western Sudan.
MedLine Citation:
PMID:  6830139     Owner:  NLM     Status:  MEDLINE    
Serum samples from girls from an elementary school in Western Sudan with grades O, I and II/III goitre were examined for their thiocyanate, cysteine, thyroxine, TSH and T3 concentrations. The concentrations of thiocyanate in all girls was higher than that reported in the literature for Nigerians, but the concentrations of thiocyanate were nevertheless significantly elevated, and those of thyroxine significantly lowered in girls with grades I and II/III goitre as compared with grade O. There were no significant differences between any of the groups in the concentrations of cysteine or TSH and T3. The predominant staple food eaten in this area of Sudan is millet and evidence is produced that this contains a goitrogenic thionamide which could be a factor in causing the endemic goitre.
A K Osman; T K Basu; J W Dickerson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  27     ISSN:  0250-6807     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  1983  
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  IM    
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MeSH Terms
Cereals / adverse effects*
Goiter, Endemic / chemically induced,  etiology*
Panicum / adverse effects*
Spectrophotometry, Ultraviolet
Thiocyanates / blood
Thyrotropin / blood
Thyroxine / blood
Triiodothyronine / blood
Reg. No./Substance:
0/Isothiocyanates; 0/Thiocyanates; 3129-90-6/isothiocyanic acid; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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