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Is glycyrrhizin sensitivity increased in anorexia nervosa and should licorice be avoided? Case report and review of the literature.
MedLine Citation:
PMID:  20739148     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: Hypokalemia is a potentially life-threatening electrolyte disturbance in anorexia nervosa and is most frequently caused by purging behavior. We report a case of severe hypokalemia in anorexia nervosa induced by daily ingestion of approximately 20 g of licorice.
METHODS: To confirm the diagnosis of licorice-induced pseudohyperaldosteronism, a re-exposure trial was performed.
RESULTS: Cessation of the licorice intake normalized plasma potassium, renin, and aldosterone levels and the urine cortisol/cortisone ratio. Re-exposure confirmed the diagnosis. The pronounced response to a relatively low daily dose of licorice suggests high glycyrrhizin sensitivity.
CONCLUSION: Patients with anorexia nervosa not only have decreased food intake but also selective and sometimes bizarre eating habits that, in association with increased sensitivity to glycyrrhizin, may cause severe hypokalemia.
Authors:
René K Støving; Linnéa E Lingqvist; Rasmus K Bonde; Alin Andries; Marianne H Hansen; Marianne Andersen; Kirsten Hørder
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Publication Detail:
Type:  Journal Article     Date:  2010-08-24
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  27     ISSN:  1873-1244     ISO Abbreviation:  Nutrition     Publication Date:    2011 Jul-Aug
Date Detail:
Created Date:  2011-06-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  855-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Center for Eating Disorders and Department of Endocrinology, Odense University Hospital, Denmark University of Southern Denmark, Odense, Denmark.
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