Document Detail

The glycosaminoglycans in menisci in experimental and natural osteoarthritis.
MedLine Citation:
PMID:  6401994     Owner:  NLM     Status:  MEDLINE    
The glycosaminoglycans in the menisci of beagles 5--7 years old were analyzed at various times after osteoarthritis was induced by sectioning the anterior cruciate ligament of one knee; the unoperated knee served as control. In the first month after induction, there were signs of inflammation in the operated joint. After 1 week, the water content was elevated and the glycosaminoglycan content (per dry weight) was reduced. The content of keratan sulfate decreased more than that of chondroitin sulfate, but the hyaluronic acid content did not change consistently. The relative proportions of chondroitin-4-sulfate, chondroitin-6-sulfate, and dermatan sulfate remained unchanged. After 3--18 months, the glycosaminoglycan levels reverted to normal, and there was some evidence that after 15--18 months, they were elevated above normal. These results, together with results obtained from single examples of mild and severe osteoarthritis in working foxhounds, suggest that, in contrast to articular cartilage, the meniscus is capable of some regeneration in response to injury.
M E Adams; M E Billingham; H Muir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  26     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  69-76     Citation Subset:  AIM; IM    
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MeSH Terms
Body Water / analysis
Chondroitin Sulfates / analysis
Dermatan Sulfate / analysis
Glycosaminoglycans / analysis*
Hyaluronic Acid / analysis
Keratan Sulfate / analysis
Menisci, Tibial / analysis*
Osteoarthritis / etiology,  metabolism*
Uronic Acids / analysis
Reg. No./Substance:
0/Glycosaminoglycans; 0/Uronic Acids; 24967-94-0/Dermatan Sulfate; 9004-61-9/Hyaluronic Acid; 9007-28-7/Chondroitin Sulfates; 9056-36-4/Keratan Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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