| The glycated albumin to glycated haemoglobin ratio increases along with the fibrosis stage in non-alcoholic steatohepatitis. | |
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MedLine Citation:
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PMID: 22715293 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: We previously reported that the indicator of glycaemic control, glycated albumin (GA) levels, are low in relation to glycaemia in patients with high alanine aminotransferase (ALT) levels in non-alcoholic fatty liver disease because of chronic inflammation, and that the GA/glycated haemoglobin ratio (G/H ratio) is inversely correlated with hepatic function in patients with chronic liver disease. The severity of liver fibrosis is known to be a good indicator for surveillance, and for determining the prognosis and optimal treatment of non-alcoholic steatohepatitis (NASH). In this study, we aimed to investigate the clinical usefulness of measuring the G/H ratio for predicting the severity of liver fibrosis in patients with NASH. METHODS: The study subjects were 36 patients with histologically diagnosed NASH (19 men, 17 women; mean age54.8 ± 12.2 years, body mass index 28.3 ± 5.0 kg/m(2)). The relationships of the G/H ratio to hepatic function tests and fibrosis stage in the liver were investigated. RESULTS: The G/H ratio in patients with NASH was inversely correlated with ALT (P < 0.001) and platelet count (P < 0.0001). Furthermore, the G/H ratio was positively correlated with the fibrosis stage in liver (P = 0.003). CONCLUSIONS: These results suggest that the G/H ratio increases along with the fibrosis stage in patients with NASH. |
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Authors:
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Yukihiro Bando; Hideo Kanehara; Keiko Aoki; Daishy Toya; Kazuo Notsumata; Nobuyoshi Tanaka; Hirayuki Enomoto; Shu-Hei Nishiguchi; Keiji Nakasho; Hideji Nakamura; Soji Kasayama; Masafumi Koga |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-19 |
Journal Detail:
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Title: Annals of clinical biochemistry Volume: - ISSN: 1758-1001 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0324055 Medline TA: Ann Clin Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Fukui-ken Saiseikai Hospital, Fukui 918-8503. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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