| The glucocorticoid contribution to obesity. | |
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MedLine Citation:
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PMID: 21294656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obesity is fast becoming the scourge of our time. It is one of the biggest causes of death and disease in the industrialized world, and affects as many as 32% of adults and 17% of children in the USA, considered one of the world's fattest nations. It can also cost countries billions of dollars per annum in direct and indirect care, latest estimates putting the USA bill for obesity-related costs at $147 billion in 2008. It is becoming clear that the pathophysiology of obesity is vastly more complicated than the simple equation of energy in minus energy out. A combination of genetics, sex, perinatal environment and life-style factors can influence diet and energy metabolism. In this regard, psychological stress can have significant long-term impact upon the propensity to gain and maintain weight. In this review, we will discuss the ability of psychological stress and ultimately glucocorticoids (GCs) to alter appetite regulation and metabolism. We will specifically focus on (i) GC regulation of appetite and adiposity, (ii) the apparent sexual dimorphism in stress effects on obesity and (iii) the ability of early life stress to programme obesity in the long term. |
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Authors:
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Sarah J Spencer; Alan Tilbrook |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-02-06 |
Journal Detail:
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Title: Stress (Amsterdam, Netherlands) Volume: 14 ISSN: 1607-8888 ISO Abbreviation: Stress Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-13 Completed Date: 2011-08-05 Revised Date: 2012-03-19 |
Medline Journal Info:
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Nlm Unique ID: 9617529 Medline TA: Stress Country: England |
Other Details:
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Languages: eng Pagination: 233-46 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Medicine, Monash UniversityMelbourne, Vic., Australia. sarah.spencer@monash.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue, Brown
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drug effects,
physiology Adipose Tissue, White / drug effects, physiology Adiposity / drug effects Adult Animals Appetite / drug effects Child Eating / drug effects Female Glucocorticoids / physiology* Gonadal Steroid Hormones / physiology Humans Hypothalamo-Hypophyseal System / physiology Insulin / secretion Male Obesity / etiology* Pituitary-Adrenal System / physiology Sex Factors Stress, Psychological / complications* |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Gonadal Steroid Hormones; 0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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