| β-glucan from barley and its lipid-lowering capacity: a meta-analysis of randomized, controlled trials. | |
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MedLine Citation:
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PMID: 20924392 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background/Objectives:To more precisely quantify the effect of barley β-glucan on blood lipid concentrations in humans and to examine the factors that could affect its efficacy.Subjects/Methods:Eleven eligible randomized clinical trials published from 1989 to 2008 were identified from nine databases. Weighted mean effect sizes were calculated for net differences in lipid profile using a random effect model (RevMan 4.2).Results:Overall, barley and β-glucan isolated from barley lowered total and low-density lipoprotein (LDL) cholesterol concentrations by 0.30 mmol/l (95% confidence interval (CI): -0.39 to -0.21, P<0.00001) and 0.27 mmol/l (95% CI: -0.34 to -0.20, P<0.00001), respectively, compared with control. The pattern of cholesterol-lowering action of barley in this analysis could not be viewed as a dose-dependent response. There were no significant subgroup differences by type of intervention and food matrix.Conclusions:Increased consumption of barely products should be considered as a dietary approach to reduce LDL cholesterol concentrations. |
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Authors:
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S S Abumweis; S Jew; N P Ames |
Publication Detail:
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Type: Journal Article Date: 2010-10-06 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 64 ISSN: 1476-5640 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1472-80 Citation Subset: IM |
Affiliation:
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Department of Clinical Nutrition and Dietetics, Faculty of Allied Health Sciences, The Hashemite University, Zarqa, Jordan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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