Document Detail


The glomerular mesangium: capillary support function and its failure under experimental conditions.
MedLine Citation:
PMID:  1450639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a structural analysis of the ability of the biomechanical unit consisting of mesangium and glomerular basement membrane to maintain normal capillary architecture in the face of mechanical challenges due to high intraglomerular pressures. Capillary support function may be considered in terms of the stabilization of local form (development of wall tension against capillary dilation) and global form (centripetal fixation of capillary loops to maintain higher order form). The pathologic consequences of the loss of this support are illustrated by way of experimental models of mechanical mesangial failure. Such failure may express itself as mesangial widening, increased transmesangial macromolecule "traffic," ballooning of capillary segments, and unfolding of capillary loops. Mechanisms are described by which these structural changes may lead to segmental glomerular sclerosis.
Authors:
K V Lemley; M Elger; I Koeppen-Hagemann; M Kretzler; M Nagata; T Sakai; S Uiker; W Kriz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Clinical investigator     Volume:  70     ISSN:  0941-0198     ISO Abbreviation:  Clin Investig     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1993-01-06     Completed Date:  1993-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9207154     Medline TA:  Clin Investig     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  843-56     Citation Subset:  IM    
Affiliation:
Institut für Anatomie und Zellbiologie I, Universität Heidelberg.
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MeSH Terms
Descriptor/Qualifier:
Animals
Basement Membrane / physiology
Biomechanics
Capillaries / physiology
Glomerular Mesangium / blood supply*,  ultrastructure
Kidney Failure / pathology*

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