Document Detail


A global view of antibiotic resistance.
MedLine Citation:
PMID:  19054120     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antibiotic resistance is one of the few examples of evolution that can be addressed experimentally. The present review analyses this resistance, focusing on the networks that regulate its acquisition and its effect on bacterial physiology. It is widely accepted that antibiotics and antibiotic resistance genes play fundamental ecological roles - as weapons and shields, respectively - in shaping the structures of microbial communities. Although this Darwinian view of the role of antibiotics is still valid, recent work indicates that antibiotics and resistance mechanisms may play other ecological roles and strongly influence bacterial physiology. The expression of antibiotic resistance determinants must therefore be tightly regulated and their activity forms part of global metabolic networks. In addition, certain bacterial modes of life can trigger transient phenotypic antibiotic resistance under some circumstances. Understanding resistance thus requires the analysis of the regulatory networks controlling bacterial evolvability, the physiological webs affected and the metabolic rewiring it incurs.
Authors:
Jose Luis Martinez; Alicia Fajardo; Leonor Garmendia; Alvaro Hernandez; Juan Francisco Linares; Laura Martínez-Solano; María Blanca Sánchez
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-11-13
Journal Detail:
Title:  FEMS microbiology reviews     Volume:  33     ISSN:  0168-6445     ISO Abbreviation:  FEMS Microbiol. Rev.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902526     Medline TA:  FEMS Microbiol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  44-65     Citation Subset:  IM    
Affiliation:
Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Cantoblanco, Madrid, Spain. jlmtnez@cnb.csic.es
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology*
Bacteria / drug effects*,  genetics,  metabolism
Bacterial Proteins / genetics,  metabolism
Drug Resistance, Bacterial*
Gene Expression Regulation, Bacterial
Mutation
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Bacterial Proteins

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