Document Detail

The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis.
MedLine Citation:
PMID:  19233695     Owner:  NLM     Status:  MEDLINE    
Glucose-6-phosphate deficiency is the most prevalent enzyme deficiency, with an estimated 400 million people affected worldwide. This inherited deficiency causes neonatal hyperbilirubinemia and chronic hemolytic anemia. Although most affected individuals are asymptomatic, exposure to oxidative stressors such as certain drugs or infection, can elicit acute hemolysis. To characterize the global prevalence of G6PD deficiency, we conducted a systematic review of the G6PD deficiency literature, drawing studies from various databases, including MEDLINE/Pubmed and Biosis. Selected studies included cross-sectional and longitudinal studies published between 1960 and 2008. Additionally, meta-analytic procedures were employed to assess the degree of heterogeneity amongst prevalence estimates and, where appropriate, pool them. The searches yielded a total of 280 prevalence estimates, corresponding to 88 countries. The highest prevalence rates were reported among Sub-Saharan African countries, even after adjusting for assessment method. Meta-analysis revealed a high degree of heterogeneity for regional and global prevalence estimates. This heterogeneity in reported estimates appeared to be due to differences in G6PD deficiency assessment and diagnostic procedures. The magnitude and variation in global, regional, and country-level prevalence rates of G6PD deficiency are of public health import, particularly in planning programs to improve neonatal health and in the distribution of various medications, especially antimalarial drugs, as G6PD deficiency is most prevalent in malaria-endemic areas.
Ella T Nkhoma; Charles Poole; Vani Vannappagari; Susan A Hall; Ernest Beutler
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-02-23
Journal Detail:
Title:  Blood cells, molecules & diseases     Volume:  42     ISSN:  1096-0961     ISO Abbreviation:  Blood Cells Mol. Dis.     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-04-21     Completed Date:  2009-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9509932     Medline TA:  Blood Cells Mol Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-78     Citation Subset:  IM    
Department of Epidemiology, University of North Carolina at Chapel Hill, CB#7435, 2106 McGavran-Greenberg Hall, Chapel Hill, NC 27599-7435, USA.
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MeSH Terms
Chromosomes, Human, X / genetics
Cross-Sectional Studies
Glucosephosphate Dehydrogenase Deficiency / epidemiology*,  genetics
Longitudinal Studies
Maps as Topic
Public Health
World Health
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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