Document Detail

The global burden of cholera.
MedLine Citation:
PMID:  22461716     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate the global burden of cholera using population-based incidence data and reports.
METHODS: Countries with a recent history of cholera were classified as endemic or non-endemic, depending on whether they had reported cholera cases in at least three of the five most recent years. The percentages of the population in each country that lacked access to improved sanitation were used to compute the populations at risk for cholera, and incidence rates from published studies were applied to groups of countries to estimate the annual number of cholera cases in endemic countries. The estimates of cholera cases in non-endemic countries were based on the average numbers of cases reported from 2000 to 2008. Literature-based estimates of cholera case-fatality rates (CFRs) were used to compute the variance-weighted average cholera CFRs for estimating the number of cholera deaths.
FINDINGS: About 1.4 billion people are at risk for cholera in endemic countries. An estimated 2.8 million cholera cases occur annually in such countries (uncertainty range: 1.4-4.3) and an estimated 87,000 cholera cases occur in non-endemic countries. The incidence is estimated to be greatest in children less than 5 years of age. Every year about 91,000 people (uncertainty range: 28,000 to 142,000) die of cholera in endemic countries and 2500 people die of the disease in non-endemic countries.
CONCLUSION: The global burden of cholera, as determined through a systematic review with clearly stated assumptions, is high. The findings of this study provide a contemporary basis for planning public health interventions to control cholera.
Mohammad Ali; Anna Lena Lopez; Young Ae You; Young Eun Kim; Binod Sah; Brian Maskery; John Clemens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-24
Journal Detail:
Title:  Bulletin of the World Health Organization     Volume:  90     ISSN:  1564-0604     ISO Abbreviation:  Bull. World Health Organ.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-30     Completed Date:  2012-07-30     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7507052     Medline TA:  Bull World Health Organ     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  209-218A     Citation Subset:  IM    
International Vaccine Institute, SNU Research Park, Seoul, Republic of Korea.
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MeSH Terms
Cholera / epidemiology*,  mortality
Developing Countries / statistics & numerical data*
Disease Outbreaks
Health Services Accessibility
Health Services Needs and Demand
Public Health / trends*
Risk Assessment
World Health
World Health Organization

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